在头颈放射治疗中使用热塑性面罩引起的推注效应。
Bolus Effect Caused by Use of Thermoplastic Masks in Head and Neck Radiotherapy Treatments.
发表日期：2024 Aug 22
作者：
Diego A Barajas-Lopez, Cristian C Castellanos-Jerez, José A Diaz-Merchan, S A Martinez-Ovalle
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
摘要：
本文研究了在通过放射疗法治疗头颈癌时使用热塑性面罩所产生的剂量不确定性。这项研究是使用蒙特卡罗 N 粒子扩展（MCNPX 代码）通过蒙特卡罗模拟进行的，并将理论结果与放射变色薄膜进行了比较。使用材料表征技术，对热塑性掩模的化合物进行了鉴定，确认大部分材料对应于聚合物 C10H16O4。理论结果显示，与没有掩模的吸收剂量相比，6 MV 和 15 MV 光子束的表面吸收剂量分别增加了 42% 到 57.4%。实验数据证实了这些发现，显示与不戴面罩的预期表面吸收剂量相比，剂量增加了 18.4% 至 52.1%。这些结果强调，在精确、安全的放射治疗计划和应用过程中，需要考虑热塑性面罩引起的推注效应，以确保其治疗效果并最大限度地降低患者的相关风险。
This paper examines the dosimetric uncertainty arising from the use of thermoplastic masks in the treatment of head and neck cancer through radiotherapy. This study was conducted through Monte Carlo simulations using the Monte Carlo N-Particle eXtended (MCNPX code), and the theoretical results are compared with radiochromic films. Using material characterization techniques, the compounds of the thermoplastic mask were identified, confirming that most of the material corresponds to the polymer C10H16O4. The theoretical results show increases ranging from 42% to 57.4% in the surface absorbed dose for 6 and 15 MV photon beams, respectively, compared to the absorbed dose without the mask. The experimental data corroborate these findings, showing dose increases ranging from 18.4% to 52.1% compared to the expected surface absorbed dose without the mask. These results highlight the need to consider the bolus effect induced by thermoplastic masks during the precise and safe planning and application of radiotherapy treatment in order to ensure its therapeutic efficacy and minimize the associated risks to patients.