基于2022年WHO甲状腺肿瘤分类的乳头状甲状腺癌超声检查结果的比较
Comparison of ultrasound findings of papillary thyroid carcinoma subtypes based on the 2022 WHO classification of thyroid neoplasms
影响因子:4.60000
分区:医学3区 / 内分泌学与代谢3区
发表日期:2024
作者:
İlhan Hekimsoy, Yeşim Ertan, Gürdeniz Serin, Ahmet Kasım Karabulut, Süha Süreyya Özbek
摘要
The present study aimed to analyze and compare sonographic features of papillary thyroid carcinoma (PTC) subtypes to determine whether ultrasound (US) may aid in differentiating particular subtypes.This retrospective study enrolled 133 patients diagnosed with 142 histopathologically proven PTCs as per the fifth edition of the World Health Organization classification of thyroid neoplasms between January 2013 and May 2023.评估并进行了比较，基于美国放射学和欧洲甲状腺成像和报告数据系统（TIRADS）以及结节的组织病理学特征的美国功能。组织病理学分析产生55（38.7％）经典PTC，32（22.5％），32（22.5％）概括了封闭的雾化卵泡（22.5％）in Invaspaled Follicull follicular volliant subsuiant（iefv）ptcy（iefv）ptc，14.1％，14。1.14.15（14.1％），14.1.14。1.14.1。 （9.9％）具有乳头状核特征（NIFTP），11（7.8％）浸润性卵泡亚型，7（4.9％）高细胞亚型，2（1.4％）固体亚型和1（0.7％）的固体底型和1（0.7％）的固定贴层的固定贴层的底层底层。美国的发现表明恶性肿瘤，例如较高的形状，不规则的边缘，回声焦点和更高的TIRADS类别，在具有经典PTC和高大的细胞亚型的结节中更常见，与他们的组织病理学特征一致。相反，IEFV-PTC和NIFTP很少表现出这些高风险超声检查功能。我们更频繁地与IEFV-PTC重叠的癌细胞亚型的外观，但是较大的结节直径和较高Tirads得分的低/非常低回声结节可能有利于诊断某些子类型的subtype.us。但是，仅使用美国图像就无法使用确定的亚型。
Abstract
The present study aimed to analyze and compare sonographic features of papillary thyroid carcinoma (PTC) subtypes to determine whether ultrasound (US) may aid in differentiating particular subtypes.This retrospective study enrolled 133 patients diagnosed with 142 histopathologically proven PTCs as per the fifth edition of the World Health Organization classification of thyroid neoplasms between January 2013 and May 2023. US features based on the American College of Radiology and European Thyroid Imaging and Reporting Data Systems (TIRADS), and histopathological characteristics of nodules were assessed and compared.Histopathological analysis yielded 55 (38.7%) classic PTC, 32 (22.5%) invasive encapsulated follicular variant (IEFV) PTC, 20 (14.1%) oncocytic subtype, 14 (9.9%) non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 11 (7.8%) infiltrative follicular subtype, 7 (4.9%) tall cell subtype, 2 (1.4%) solid subtype, and 1 (0.7%) diffuse sclerosing subtype. The US findings indicating malignancy, such as taller-than-wide shape, irregular margins, echogenic foci, and higher TIRADS categories, were more frequently demonstrated in nodules with classic PTC and the tall cell subtype, in line with their histopathological features. Conversely, IEFV-PTC and NIFTP rarely exhibited these high-risk sonographic features. US appearance of the oncocytic subtype more frequently overlapped with IEFV-PTC, yet hypo/very hypoechoic nodules with larger nodular diameters and higher TIRADS scores may favor the diagnosis of this subtype.US features of certain subtypes may guide the differential diagnosis regarding shape, margin, echogenic foci, and TIRADS category of nodules; however, definitive subtyping is not yet possible using US images alone.