线粒体免疫检查点的代谢调节。
Metabolic regulation of the mitochondrial immune checkpoint.
发表日期：2024
作者：
David C Montrose, Suchandrima Saha, Lorenzo Galluzzi
来源：
OncoImmunology
摘要：
破坏恶性细胞中的线粒体功能是增强抗癌免疫力的一种有前景的策略。我们最近证明，剥夺结直肠癌细胞的丝氨酸会导致线粒体功能障碍，同时线粒体 DNA 在胞质中积累，从而激活 CGAS 和 STING 依赖性肿瘤靶向免疫反应。© 2024 作者。经泰勒许可出版
Disrupting mitochondrial function in malignant cells is a promising strategy to enhance anticancer immunity. We have recently demonstrated that depriving colorectal cancer cells of serine results in mitochondrial dysfunction coupled with the cytosolic accumulation of mitochondrial DNA and consequent activation of CGAS- and STING-dependent tumor-targeting immune responses.© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.