当归补血汤（DGBX）是由黄芪（AR）和当归（ASR）组成的经典方剂，具有补血、益气的功效，具有恢复能量和促进新陈代谢的潜力。慢性炎症是炎症性肠病（IBD）相关结直肠癌（CRC）发展的危险因素。更重要的是，AR和ASR具有抗炎和抗癌活性，并预示着对炎症向癌症转化的潜在影响。因此，我们的目的是回顾 DGBX 煎剂及其成分在这种恶性转化中的免疫代谢潜力，为管理 IBD-CRC 风险提供有益的补充。本研究探讨了DGBX汤剂及其整个成分AR和ASR的多方面作用，包括抗炎作用、抗癌特性、免疫调节和代谢调节。该评估综合了学术文献，包括过去 20 年来从 PubMed、Web of Science 和 Scopus 数据库中检索到的 200 多篇文章。检索策略采用“当归补血”、“黄芪”、“当归”、“炎症”、“新陈代谢”等关键词以及相关同义词，特别注重高质量的研究和研究成果重大发现。 DGBX 汤剂在调节免疫代谢方面的潜力有望治疗 IBD 相关的 CRC。考虑到 CRC 的异质性和个性化医疗的日益增长的趋势，这一点尤其重要，但精确和详细的机制需要进一步的体内验证和广泛的临床研究，以证实免疫代谢调节并描绘所涉及的途径。© 2024。作者）。

Danggui Buxue (DGBX) decoction is a classical prescription composed of Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), used to enrich blood, and nourish Qi in Chinese medicine, with the potential to recover energy and stimulate metabolism. Chronic inflammation is a risk factor in the development of inflammatory bowel disease (IBD)-related colorectal cancer (CRC). More importantly, AR and ASR have anti-inflammatory and anti-cancer activities, as well as prefiguring a potential effect on inflammation-cancer transformation. We, therefore, aimed to review the immunometabolism potential of DGBX decoction and its components in this malignant transformation, to provide a helpful complement to manage the risk of IBD-CRC. The present study investigates the multifaceted roles of DGBX decoction and its entire components AR and ASR, including anti-inflammation effects, anti-cancer properties, immune regulation, and metabolic regulation. This assessment is informed by a synthesis of scholarly literature, with more than two hundred articles retrieved from PubMed, Web of Science, and Scopus databases within the past two decades. The search strategy employed utilized keywords such as "Danggui Buxue", "Astragali Radix", "Angelicae Sinensis Radix", "Inflammation", and "Metabolism", alongside the related synonyms, with a particular emphasis on high-quality research and studies yielding significant findings. The potential of DGBX decoction in modulating immunometabolism holds promise for the treatment of IBD-related CRC. It is particularly relevant given the heterogeneity of CRC and the growing trend towards personalized medicine, but the precise and detailed mechanism necessitate further in vivo validation and extensive clinical studies to substantiate the immunometabolic modulation and delineate the pathways involved.© 2024. The Author(s).