结直肠癌很常见，预后正在改善。因此，治疗幸存者的状况，包括经济后果，非常重要。本研究的目的是量化工作年龄的结肠癌和直肠癌患者相对于匹配对照者的收入损失和工作损失。该研究利用了 CRCBaSe 数据库的数据，该数据库由全国瑞典结肠直肠癌登记处生成，包括数据来自几个瑞典全国登记册。直肠癌患者的研究时间为1995-2020年，结肠癌患者的研究时间为2007-2020年。对 I-III 期结直肠癌治疗幸存者的收入、可支配收入和工作损失进行了一项基于人群的回顾性全国队列研究。使用中位数回归分析收入和可支配收入，使用逻辑回归分析失业概率。对 2017 年之前诊断的 8863 名结直肠癌幸存者和 52,514 名在出生年份、法定性别和居住县进行匹配的对照者进行了分析。诊断前一年和诊断后一年之间，收入明显减少，结肠癌患者从 31,319 欧元降至 23,924 欧元，直肠癌患者从 32,636 欧元降至 22,647 欧元，并且收入在这 5 年期间从未完全恢复。年随访。可支配收入几乎没有变化。结肠癌和直肠癌患者在确诊当年失业的概率从前一年的29.8%上升到25.3%，分别上升到83.3%和84.4%，并且从未完全康复。结肠癌和直肠癌幸存者之间失业的可能性相似，但接受新辅助治疗的直肠癌患者失业的可能性更高。这项研究表明，尽管广泛的福利制度提供了可维持的可支配收入，但仍存在以下形式的经济负担：结直肠癌幸存者失业风险增加和收入减少。该研究得到了瑞典癌症协会、瑞典癌症和过敏基金会以及斯德哥尔摩癌症协会的支持，并得到了区域协议提供的赠款支持斯德哥尔摩郡议会和卡罗林斯卡学院之间的医学培训和临床研究 (ALF)。© 2024 作者。

Colorectal cancer is common and prognosis is improving. The conditions of survivors of treatment, including financial consequences, are thus important. The aim of this study was to quantify loss of earnings and work loss in working-age patients with colon and rectal cancer relative to matched comparators.The study utilised data from the CRCBaSe database that is generated from the nationwide Swedish ColoRectal Cancer Register and includes data from several Swedish nationwide registers. The study period was 1995-2020 for rectal cancer patients and 2007-2020 for colon cancer patients. A retrospective population-based nationwide cohort study on earnings, disposable income, and work loss, in survivors of stage I-III colorectal cancer treatment was undertaken. Median regression was used to analyse earnings and disposable income, and logistic regression to analyse the probability of work loss.A cohort of 8863 colorectal cancer survivors diagnosed before 2017 and 52,514 comparators matched on birth year, legal sex, and county of residence, was analysed. There was a clear reduction in earnings between the calendar year prior to and the calendar year after diagnosis, from € 31,319 to € 23,924 for colon cancer patients and from € 32,636 to € 22,647 for rectal cancer patients, and earnings never fully recovered during the 5-year follow-up. Disposable income was practically unaltered. The probability of work loss increased in the calendar year of diagnosis, from 29.8% to 25.3% the previous year to 83.3% and 84.4% for colon and rectal cancer patients respectively, and never fully recovered. The probability of work loss was similar between colon and rectal cancer survivors, but was higher among patients with rectal cancer who had received neoadjuvant therapy.This study shows that despite an extensive welfare system providing maintained disposable income, there is a financial burden in the form of increased risk of work loss and a reduction in earnings among survivors of colorectal cancer.The study was supported by the Swedish Cancer Society, the Swedish Cancer and Allergy Foundation, and the Stockholm Cancer Society, and supported by grants provided by the Regional Agreement on Medical Training and Clinical Research (ALF) between the Stockholm County Council and Karolinska Institutet.© 2024 The Author(s).