肺部疾病中高浓度氢的抗炎和抗氧化活性：系统评价和荟萃分析
Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: a systematic review and meta-analysis
影响因子:5.90000
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, Yong Yang, Zhifeng Pan, Peng Li, Zhongjun Du
摘要
作为一个小分子，氢是无色，无味和最轻的。许多研究表明，氢可以保护几乎每个器官，包括大脑，心肌，肝脏，小肠和肺部。为了验证高浓度的氢（HCH）是否在呼吸系统上具有抗炎和抗氧化活性，我们会产生系统的综述和荟萃分析。我们研究了Medline-Pubmed，Cochrane文库，科学级，Wiley和Springerlink数据库，并选择了与HCH在2023年9月发表的HCH疾病中与HCH疾病的抗炎或抗氧化作用有关的体内研究，直到2023年9月。我们首先识别了437个研究，仅识别了437个研究，并遇到了包含条件。他们都在啮齿动物中进行。结果表明，HCH对肿瘤坏死因子α（TNF-α），白介素（IL）-1β，IL-4，IL-4，IL-8，丙二醛（MDA）（MDA），超氧化物歧化酶（SOD）和活性氧氧种（ROS）（ROS）具有积极作用；但是对IL-6没有影响，我们推测可能会导致不同体液和不同时间点的测试结果。这项荟萃分析发现了对炎症和氧化应激的保护作用，但是需要进一步阐明对炎症和氧化剂介质减少的影响。
Abstract
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta-analysis. We investigated MEDLINE-PubMed, Cochrane Library, ScienceDirect, Wiley and SpringerLink database and selected in vivo studies related to the anti-inflammatory or antioxidant effects of HCH in the lung diseases which were published until September 2023. We firstly identified 437 studies and only 12 met the inclusion criteria. They all conducted in rodents. The results showed that HCH had a positive effect on the reduction of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-4, IL-8, malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS); but there is no effect on IL-6, we speculated that may contribute to the test results for different body fluids and at different points in time. This meta-analysis discovered the protective effects on inflammation and oxidative stress, but whether there exists more effects on reduction of inflammatory and oxidant mediators needs to be further elucidated.