高浓度氢气在肺部疾病中的抗炎和抗氧化活性：系统评价与Meta分析
Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: a systematic review and meta-analysis
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影响因子:5.9
分区:医学2区 / 免疫学2区
发表日期:2024
作者:
Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, Yong Yang, Zhifeng Pan, Peng Li, Zhongjun Du
DOI:
10.3389/fimmu.2024.1444958
摘要
作为一种小分子，氢气无色、无味且最轻。多项研究表明，氢气几乎可以保护所有器官，包括大脑、心肌、肝脏、小肠和肺。为了验证高浓度氢气（HCH）在呼吸系统中的抗炎和抗氧化作用，我们进行了系统评价与Meta分析。我们检索了MEDLINE-PubMed、Cochrane图书馆、ScienceDirect、Wiley和SpringerLink数据库，筛选了截至2023年9月发表的与HCH在肺部疾病中抗炎或抗氧化作用相关的体内研究。初步筛选出437篇研究，最终有12篇符合纳入标准，全部为大鼠模型。结果显示，HCH能显著降低肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-1β、IL-4、IL-8、丙二醛（MDA）、超氧化物歧化酶（SOD）和反应性氧簇（ROS）；但对IL-6无显著影响。我们推测不同体液和时间点可能影响测试结果。本Meta分析揭示了HCH在抗炎和抗氧化应激中的保护作用，但其在降低炎症和氧化介质中的其他潜在作用仍需进一步阐明。
Abstract
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta-analysis. We investigated MEDLINE-PubMed, Cochrane Library, ScienceDirect, Wiley and SpringerLink database and selected in vivo studies related to the anti-inflammatory or antioxidant effects of HCH in the lung diseases which were published until September 2023. We firstly identified 437 studies and only 12 met the inclusion criteria. They all conducted in rodents. The results showed that HCH had a positive effect on the reduction of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-4, IL-8, malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS); but there is no effect on IL-6, we speculated that may contribute to the test results for different body fluids and at different points in time. This meta-analysis discovered the protective effects on inflammation and oxidative stress, but whether there exists more effects on reduction of inflammatory and oxidant mediators needs to be further elucidated.