作为一种小分子，氢无色、无味且最轻。许多研究表明，氢气可以保护几乎所有器官，包括大脑、心肌、肝脏、小肠和肺。为了验证高浓度氢气 (HCH) 是否对呼吸系统具有抗炎和抗氧化活性，我们进行了系统评价和荟萃分析。我们调查了 MEDLINE-PubMed、Cochrane Library、ScienceDirect、Wiley 和 SpringerLink 数据库，并选择了截至 2023 年 9 月发表的与六氯环己烷在肺部疾病中的抗炎或抗氧化作用相关的体内研究。我们首先确定了 437 项研究，其中只有 12 项符合纳入标准。他们都是在啮齿动物身上进行的。结果表明，六氯环己烷对降低肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-1β、IL-4、IL-8、丙二醛（MDA）、超氧化物歧化酶（SOD）和反应活性有积极作用。氧物质（ROS）；但对IL-6没有影响，我们推测这可能有助于不同体液和不同时间点的检测结果。这项荟萃分析发现了对炎症和氧化应激的保护作用，但是否存在更多减少炎症和氧化介质的作用还需要进一步阐明。版权所有 © 2024 肖，刘，孙，陈，马，曹，杨，潘、李、杜。

As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta-analysis. We investigated MEDLINE-PubMed, Cochrane Library, ScienceDirect, Wiley and SpringerLink database and selected in vivo studies related to the anti-inflammatory or antioxidant effects of HCH in the lung diseases which were published until September 2023. We firstly identified 437 studies and only 12 met the inclusion criteria. They all conducted in rodents. The results showed that HCH had a positive effect on the reduction of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-4, IL-8, malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS); but there is no effect on IL-6, we speculated that may contribute to the test results for different body fluids and at different points in time. This meta-analysis discovered the protective effects on inflammation and oxidative stress, but whether there exists more effects on reduction of inflammatory and oxidant mediators needs to be further elucidated.Copyright © 2024 Xiao, Liu, Sun, Chen, Ma, Cao, Yang, Pan, Li and Du.