含有甘油的壳聚糖膜可以作为不同抗生素或活性成分的有效分散剂，可用于治疗口腔疾病。添加甘油对机械、吸水性、膨胀、pH、本研究对壳聚糖-氯己定-甘油膜的厚度、崩解性、粗糙度和抗菌性能进行了研究。力学结果表明，壳聚糖膜的粗糙度、强度、弯曲度和厚度在加载1、3、5、10、15、和 20% 甘油 (p < 0.05)。 3%、5% 和 10% 浓度的甘油的存在显着增强了壳聚糖膜的粗糙度、溶解度、强度和 pH 结果。在本研究中，使用的抗菌活性模型是壳聚糖-氯己定膜对变形链球菌 CDBB-B-1455 的抑制。观察到不同浓度的甘油的抑制没有变化。结果表明，壳聚糖-甘油-氯己定膜可能是局部防腐剂应用的潜在候选者，用于治疗由变形链球菌引起的颊齿疾病，如龋齿、牙周病和口腔鳞状细胞癌，有助于预防严重口腔疾病的发展。版权 © 2024 Hachity-Ortega、Jerezano-Domínguez、Pazos-Rojas、Flores-Ledesma、Pazos-Guarneros、Parra-Solar、Reyes-Cervantes、Juárez-Díaz、Medina、González-Martínez、Castillo-席尔瓦、阿维拉-库里尔、埃尔南德斯-华雷斯、里维拉-乌尔巴莱霍、戈迪略-格拉和卡西利亚斯-桑塔纳。

Chitosan membranes with glycerol can function as an effective dispersing agent for different antibiotics or active ingredients that can be used in the treatment of diseases present in the oral cavity.The effects of the addition of glycerol on the mechanical, water absorption, swelling, pH, thickness, disintegration, rugosity, and antibacterial properties of chitosan-chlorhexidine- glycerol membranes were investigated in this study.Mechanical results indicated that chitosan membranes' rugosity, strength, flexion, and thickness differed at loading 1, 3, 5, 10, 15, and 20% of glycerol (p < 0.05). The chitosan membranes' rugosity, dissolution, strength, and pH results were significantly enhanced by the presence of glycerol at 3, 5, and 10% concentrations. In this investigation, the antimicrobial activity model used was the inhibition of Streptococcus mutans CDBB-B-1455 by chitosan-chlorhexidine membranes. It was observed that there was no change in inhibition with different concentrations of glycerol. The results suggest that chitosan-glycerol-chlorhexidine membranes may be a potential candidate for topical antiseptic application in buccal-dental disorders caused by S. mutans, such as caries, periodontal diseases, and oral squamous cell carcinoma, helping to prevent the development of serious conditions that can compromise human health.Copyright © 2024 Hachity-Ortega, Jerezano-Domínguez, Pazos-Rojas, Flores-Ledesma, Pazos-Guarneros, Parra-Solar, Reyes-Cervantes, Juárez-Díaz, Medina, González-Martínez, Castillo-Silva, Ávila-Curiel, Hernández-Juárez, Rivera-Urbalejo, Gordillo-Guerra and Casillas-Santana.