肝癌是最致命的胃肠道恶性肿瘤之一。新的证据强调了长非编码RNA（lncRNA）在肿瘤发生中的关键作用，其中ST8SIA6-AS1被确定为一种新型致癌lncRNA，有助于肝癌进展。 ST8SIA6-AS1 在肝癌组织中持续上调，与不良预后密切相关。此外，它在检测 HCC 方面表现出很高的诊断功效。 ST8SIA6-AS1 主要通过其作为竞争性内源 RNA (ceRNA) 的功能参与多种细胞过程，包括增殖、迁移和侵袭，从而促进肝癌发生和疾病进展。本综述详细研究了 ST8SIA6-AS1 在肝细胞癌 (HCC) 中的分子功能和调控机制，并强调了其作为肝癌生物标志物的潜力，旨在推动 HCC 管理创新治疗策略的开发。版权所有 © 2024 邱、范、陶、邓、罗、刘。

Liver cancer is one of the most lethal gastrointestinal malignancies. Emerging evidence has underscored the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis, with ST8SIA6-AS1 identified as a novel oncogenic lncRNA contributing to liver cancer progression. ST8SIA6-AS1 is consistently upregulated in hepatic cancer tissues and is strongly associated with unfavorable prognosis. Moreover, it demonstrates high diagnostic efficacy in detecting HCC. ST8SIA6-AS1 is involved in various cellular processes including proliferation, migration, and invasion, primarily through its function as a competing endogenous RNA (ceRNA), thereby facilitating hepatocarcinogenesis and disease advancement. This review provides a detailed examination of the molecular functions and regulatory mechanisms of ST8SIA6-AS1 in hepatocellular carcinoma (HCC) and highlights its potential as a promising biomarker for liver cancer, aiming to propel the development of innovative therapeutic strategies for HCC management.Copyright © 2024 Qiu, Fan, Tao, Deng, Luo and Liu.