额后上回 (PSFG) 肿瘤切除后，患者可能会出现辅助运动区 (SMA) 综合征，包括对侧偏侧失用和/或言语失用。鉴于 PSFG 肿瘤的异质性，作者试图确定术后缺陷的风险，并评估所有接受手术（活检或切除）的实质内 PSFG 肿瘤的结果预测因素，无论组织学如何。这是一项针对成人的回顾性单中心队列研究由一名外科医生进行活检或切除的 PSFG 区域肿瘤。共有 106 名连续患者接受了 123 次手术（21 次活检，102 次切除），符合纳入和排除标准。间变性星形细胞瘤在切除的肿瘤中最常见（39% vs 29%），而胶质母细胞瘤在活检中最常见（38% vs 27%）（p < 0.0001）。活检队列更有可能在 PSFG 之外出现肿瘤受累（90% vs 62%）（p = 0.011），最常见的是运动皮层（67% vs 31%）（p = 0.005）。癫痫发作是切除组中最常见的症状 (p = 0.017)，而运动缺陷在活检组中更常见 (58% vs 29%) (p < 0.001)。 71 例 (58%) 患者术后即刻出现神经功能缺损，但只有 3 例在随访 6 个月时出现永久性神经功能缺损 (2%)。术后 SMA 综合征发生于 48 例 (47%)，并且与运动皮层 (p = 0.018) 或扣带回 (p = 0.023) 受累显着相关，这在多变量分析中作为 SMA 综合征的危险因素也很重要。然而，术后 SMA 综合征与总生存率没有显着相关性 (p = 0.51)。没有围手术期死亡，但胼胝体受累 (p < 0.001)、对比增强 (p = 0.003) 和胶质母细胞瘤病理学 (p = 0.038) 预测接受切除的患者总生存期较差。 近一半接受 PSFG 切除的患者-区域肿瘤会出现术后 SMA 综合征。胼胝体和/或运动皮层受累的个体患 SMA 综合征的风险可能增加。然而，这些赤字通常是暂时的，永久性新赤字的风险非常低（3%）。除了病理学之外，术前特征包括胼胝体受累和肿瘤增强，可能可以作为该患者群体总体生存率的预测因素。

Following resection of posterior superior frontal gyrus (PSFG) tumors, patients can experience supplementary motor area (SMA) syndrome consisting of contralateral hemiapraxia and/or speech apraxia. Given the heterogeneity of PSFG tumors, the authors sought to determine the risk of postoperative deficits and assess predictors of outcomes for all intraparenchymal PSFG tumors undergoing surgery (biopsy or resection), regardless of histology.This was a retrospective single-center cohort study of adult PSFG-region tumors undergoing biopsy or resection by a single surgeon.A total of 106 consecutive patients undergoing 123 procedures (21 biopsies, 102 resections) fulfilled inclusion and exclusion criteria. Anaplastic astrocytomas were the most frequent among resected tumors (39% vs 29%), while glioblastomas were most common among biopsies (38% vs 27%) (p < 0.0001). The biopsy cohort was more likely to have tumor involvement outside the PSFG (90% vs 62%) (p = 0.011), most commonly in the motor cortex (67% vs 31%) (p = 0.005). Seizures were the most common presenting symptom in the resection cohort (p = 0.017), while motor deficits were more common in the biopsy cohort (58% vs 29%) (p < 0.001). Immediate postoperative neurological deficits occurred in 71 cases (58%), but only 3 of the deficits were permanent at 6 months of follow-up (2%). Postoperative SMA syndrome occurred in 48 cases (47%) and was significantly associated with involvement of the motor cortex (p = 0.018) or cingulate gyrus (p = 0.023), which were also significant in multivariate analysis as risk factors for SMA syndrome. However, postoperative SMA syndrome was not significantly associated with overall survival (p = 0.51). There were no perioperative deaths, but corpus callosum involvement (p < 0.001), contrast enhancement (p = 0.003), and glioblastoma pathology (p = 0.038) predicted worse overall survival in patients undergoing resection.Nearly half of all patients undergoing resection of PSFG-region tumors experience a postoperative SMA syndrome. Individuals with corpus callosum and/or motor cortex involvement may be at an increased risk of experiencing SMA syndrome. However, these deficits are usually transient, and the risk of permanent new deficits is very low (3%). Preoperative characteristics including corpus callosum involvement and tumor enhancement-in addition to pathology-might serve as predictors of overall survival within this patient population.