在肿瘤微环境中，巨噬细胞响应不同的信号表现出不同的表型和功能，在肿瘤的发生和进展中发挥着至关重要的作用。多项研究表明，干预肿瘤相关巨噬细胞不同表型的功能会导致肿瘤细胞与免疫相关细胞（如 T、NK 和 B 细胞）之间的串扰发生显着变化，从而显着改变肿瘤的发展进程。然而，目前只有少数针对巨噬细胞的特异性治疗策略可用。本文全面综述了肿瘤相关巨噬细胞介导肿瘤细胞与免疫相关细胞之间串扰的分子生物学机制。此外，还总结了目前临床实践和临床试验阶段使用的各种治疗方法，并对针对肿瘤相关巨噬细胞的新策略进行了相应分类。版权所有 © 2024。 Published by Elsevier B.V.

In the tumor microenvironment, macrophages exhibit different phenotypes and functions in response to various signals, playing a crucial role in the initiation and progression of tumors. Several studies have indicated that intervention in the functions of different phenotypes of tumor-associated macrophages causes significant changes in the crosstalk between tumor cells and immune-related cells, such as T, NK, and B cells, markedly altering the course of tumor development. However, only a few specific therapeutic strategies targeting macrophages are yet available. This article comprehensively reviews the molecular biology mechanisms through which tumor-associated macrophages mediate the crosstalk between tumor cells and immune-related cells. Also, various treatment methods currently used in clinical practice and those in the clinical trial phase have been summarized, and the novel strategies for targeting tumor-associated macrophages have been categorized accordingly.Copyright © 2024. Published by Elsevier B.V.