基于 miRNA 的卵巢癌电化学生物传感器。
miRNA-based electrochemical biosensors for ovarian cancer.
发表日期：2024 Aug 28
作者：
Saber Rouhi, Hassan Ghasemi, Mehdi Alizadeh, Ahmad Movahedpour, Farzaneh Vahedi, Mehdi Fattahi, Saleh Aiiashi, Seyyed Hossein Khatami
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
卵巢癌是女性中一种常见且致命的癌症，由于其异质性，对早期检测提出了重大挑战。 MicroRNA 是短的非编码调节 RNA 片段，在各种细胞过程中发挥作用。在许多癌症类型的致癌相关过程中观察到这些 microRNA 的异常表达。大量研究强调了 microRNA 在卵巢癌发生和进展中的关键作用。鉴于其临床重要性和预测价值，人们对开发简单、迅速且灵敏的 miRNA 生物传感器策略产生了极大的兴趣。其中，电化学传感器表现出简单、灵敏、低成本和可扩展性等优点。这些基于 microRNA 的电化学生物传感器是早期检测和护理点应用的宝贵工具。本文讨论了 microRNA 在卵巢癌中的潜在作用，以及用于卵巢癌样本中 miRNA 检测的电化学生物传感器开发的最新进展。版权所有 © 2024 Elsevier B.V. 保留所有权利。
Ovarian cancer, a prevalent and deadly cancer among women, presents a significant challenge for early detection due to its heterogeneous nature. MicroRNAs, short non-coding regulatory RNA fragments, play a role in various cellular processes. Aberrant expression of these microRNAs has been observed in the carcinogenesis-related processes of many cancer types. Numerous studies highlight the critical role of microRNAs in the initiation and progression of ovarian cancer. Given their clinical importance and predictive value, there has been considerable interest in developing simple, prompt, and sensitive miRNA biosensor strategies. Among these, electrochemical sensors have demonstrated advantageous characteristics such as simplicity, sensitivity, low cost, and scalability. These microRNA-based electrochemical biosensors are valuable tools for early detection and point-of-care applications. This article discusses the potential role of microRNAs in ovarian cancer and recent advances in the development of electrochemical biosensors for miRNA detection in ovarian cancer samples.Copyright © 2024 Elsevier B.V. All rights reserved.