手性无机纳米材料在肿瘤微环境中的应用：癌症治疗的新篇章
Chiral inorganic nanomaterials in the tumor microenvironment: A new chapter in cancer therapy
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影响因子:10.5
分区:医学2区 Top / 药学1区
发表日期:2024 Oct
作者:
Xueyi Song, Chenjing Hao, Yao Li, Yunong Li, Hongzhi Dong, Qian Wei, Minjie Wei, Heran Li, Lin Zhao
DOI:
10.1016/j.phrs.2024.107386
摘要
手性在调控正常生理过程中起着关键作用，并在生物体内广泛存在。通过非对称组装和/或分子手性基团或连接体的接枝，手性可以赋予纳米材料，无论其是天然的还是人工合成的。手性无机纳米材料具有独特的物理和化学特性，区别于常规纳米材料。它们还能与细胞和组织以特定方式相互作用，使其在多种生物医学应用中具有潜力，尤其在肿瘤治疗中。尽管关于手性无机纳米材料在肿瘤微环境（TME）中的研究不断增加，且其潜在应用令人期待，但目前尚缺乏系统综述其与TME复杂交互的文献。在本综述中，我们介绍了手性无机纳米材料的基本概念、分类、合成方法及其理化特性。随后简要概述了TME的组成，如T细胞、巨噬细胞、树突状细胞及弱酸，并讨论了几种针对这些组成部分的手性纳米颗粒的抗肿瘤作用及其在癌症治疗中的潜在应用。最后，指出了手性无机纳米材料在癌症治疗中面临的挑战及未来的研究方向。
Abstract
Chirality plays a crucial function in the regulation of normal physiological processes and is widespread in organisms. Chirality can be imparted to nanomaterials, whether they are natural or manmade, through the process of asymmetric assembly and/or grafting of molecular chiral groups or linkers. Chiral inorganic nanomaterials possess unique physical and chemical features that set them apart from regular nanomaterials. They also have the ability to interact with cells and tissues in a specific manner, making them useful in various biomedical applications, particularly in the treatment of tumors. Despite the growing amount of research on chiral inorganic nanomaterials in the tumor microenvironment (TME) and their promising potential applications, there is a lack of literature that comprehensively summarizes the intricate interactions between chiral inorganic nanomaterials and TME. In this review, we introduce the fundamental concept, classification, synthesis methods, and physicochemical features of chiral inorganic nanomaterials. Next, we briefly outline the components of TME, such as T cells, macrophages, dendritic cells, and weak acids, and then discuss the anti-tumor effects of several chiral inorganic nanoparticles targeting these components and their potential for possible application during cancer therapy. Finally, the present challenges faced by chiral inorganic nanomaterials in cancer treatment and their future areas of investigation are disclosed.