肿瘤微环境中的手性无机纳米材料：癌症治疗的新章节
Chiral inorganic nanomaterials in the tumor microenvironment: A new chapter in cancer therapy
影响因子:10.50000
分区:医学2区 Top / 药学1区
发表日期:2024 Oct
作者:
Xueyi Song, Chenjing Hao, Yao Li, Yunong Li, Hongzhi Dong, Qian Wei, Minjie Wei, Heran Li, Lin Zhao
摘要
手性在调节正常生理过程中起着至关重要的功能，并且在生物体中是普遍的。通过不对称组装和/或分子性手性群或接头的过程，手性可以赋予纳米材料，无论是天然还是人造的。手性无机纳米材料具有独特的物理和化学特征，使它们与常规纳米材料区分开来。他们还具有特定方式与细胞和组织相互作用的能力，使其在各种生物医学应用中有用，尤其是在肿瘤的治疗中。尽管对肿瘤微环境（TME）及其有希望的潜在应用的手性无机纳米材料进行了越来越多的研究，但缺乏全面的文献总结了手性无机纳米材料和TME之间复杂的相互作用。在这篇综述中，我们介绍了手性无机纳米材料的基本概念，分类，合成方法和物理化学特征。接下来，我们简要概述了TME的成分，例如T细胞，巨噬细胞，树突状细胞和弱酸，然后讨论针对这些成分的几种手性无机纳米颗粒的抗肿瘤效应，这些纳米颗粒针对这些成分及其在癌症治疗过程中可能应用的潜力。最后，披露了手性无机纳米材料在癌症治疗中面临的挑战及其未来的调查领域。
Abstract
Chirality plays a crucial function in the regulation of normal physiological processes and is widespread in organisms. Chirality can be imparted to nanomaterials, whether they are natural or manmade, through the process of asymmetric assembly and/or grafting of molecular chiral groups or linkers. Chiral inorganic nanomaterials possess unique physical and chemical features that set them apart from regular nanomaterials. They also have the ability to interact with cells and tissues in a specific manner, making them useful in various biomedical applications, particularly in the treatment of tumors. Despite the growing amount of research on chiral inorganic nanomaterials in the tumor microenvironment (TME) and their promising potential applications, there is a lack of literature that comprehensively summarizes the intricate interactions between chiral inorganic nanomaterials and TME. In this review, we introduce the fundamental concept, classification, synthesis methods, and physicochemical features of chiral inorganic nanomaterials. Next, we briefly outline the components of TME, such as T cells, macrophages, dendritic cells, and weak acids, and then discuss the anti-tumor effects of several chiral inorganic nanoparticles targeting these components and their potential for possible application during cancer therapy. Finally, the present challenges faced by chiral inorganic nanomaterials in cancer treatment and their future areas of investigation are disclosed.