肝细胞癌中的癌症干细胞壁细胞四分之一的四重奏
A quartet of cancer stem cell niches in hepatocellular carcinoma
影响因子:11.80000
分区:医学2区 / 生化与分子生物学2区 细胞生物学2区
发表日期:2024 Oct
作者:
Neha Balaji, Samiksha Kukal, Anjali Bhat, Nikita Pradhan, Shilpi Minocha, Saran Kumar
摘要
肝细胞癌（HCC）是最普遍的原发性肝癌类型，以其侵略性行为和预后不良而闻名。癌症干细胞理论假定了少数称为癌症干细胞（CSC）的自我更新细胞的存在，它为HCC的各种临床和分子特征提供了见解，例如肿瘤异质性，代谢适应性，治疗耐药性和再生。这些CSC是在肿瘤微环境（TME）中培养的，其中内部和外部因素的混合会产生肿瘤支持的小众生殖位，并在空间和时间上不断发展，从而增强了肿瘤的复杂性。本评论详细介绍了肝CSC（HCSC）的起源以及影响其茎状品质的因素。它突出了HCSC和TME之间的相互串扰（缺氧，血管，侵入性和免疫壁ni），探索涉及的信号传导途径以及这些相互作用如何控制CSC的恶性特征。此外，它讨论了针对HCSC利基市场的潜在治疗方法及其在临床实践中的可能用途。
Abstract
Hepatocellular Carcinoma (HCC), the most prevalent type of primary liver cancer, is known for its aggressive behavior and poor prognosis. The Cancer Stem Cell theory, which postulates the presence of a small population of self-renewing cells called Cancer Stem Cells (CSCs), provides insights into various clinical and molecular features of HCC such as tumor heterogeneity, metabolic adaptability, therapy resistance, and recurrence. These CSCs are nurtured in the tumor microenvironment (TME), where a mix of internal and external factors creates a tumor-supportive niche that is continuously evolving both spatially and temporally, thus enhancing the tumor's complexity. This review details the origins of hepatic CSCs (HCSCs) and the factors influencing their stem-like qualities. It highlights the reciprocal crosstalk between HCSCs and the TME (hypoxic, vascular, invasive, and immune niches), exploring the signaling pathways involved and how these interactions control the malignant traits of CSCs. Additionally, it discusses potential therapeutic approaches targeting the HCSC niche and their possible uses in clinical practice.