他汀类药物是广泛使用的心血管药物，通过抑制 HMG-CoA 还原酶来降低胆固醇，因其潜在的抗癌特性而受到越来越多的认可。这项研究阐明了潜在的机制，揭示了他汀类药物利用了合成致死性，即两个非致死事件同时发生导致细胞死亡的原理。我们对大约 37,000 个 SL 对的计算分析确定他汀类药物是针对具有转移基因的 SL 对中涉及的基因的潜在药物。对各种癌细胞系的体外验证证实了他汀类药物的抗癌功效。这种数据驱动的药物再利用策略为他汀类药物的抗癌作用提供了分子基础，为肿瘤学提供了转化机会。© 2024。作者。

Statins, widely used cardiovascular drugs that lower cholesterol by inhibiting HMG-CoA reductase, have been increasingly recognized for their potential anticancer properties. This study elucidates the underlying mechanism, revealing that statins exploit Synthetic Lethality, a principle where the co-occurrence of two non-lethal events leads to cell death. Our computational analysis of approximately 37,000 SL pairs identified statins as potential drugs targeting genes involved in SL pairs with metastatic genes. In vitro validation on various cancer cell lines confirmed the anticancer efficacy of statins. This data-driven drug repurposing strategy provides a molecular basis for the anticancer effects of statins, offering translational opportunities in oncology.© 2024. The Author(s).