癌症是导致死亡的主要原因之一，对全世界人民构成巨大威胁。癌症治疗方式包括手术、放疗、化疗、放化疗、激素治疗和免疫治疗。最好的方法是使用多种类型的组合。在上述治疗方法中，经常使用化疗，但其活性因耐药性的产生和许多副作用而受到阻碍。在这方面，药用植物的使用已经被讨论，近几十年来，分离的植物化学物质的使用成为人们关注的焦点。通过批判性地评估现有证据并强调本次综述提供的独特视角，我们深入了解大豆黄酮作为有前途的治疗剂的潜力，并概述未来的研究方向，以优化其在临床环境中的功效。总结治疗潜力大豆苷元（一种异黄酮植物雌激素）在治疗多种人类疾病中的应用，重点关注作为治疗剂的现状和未来前景。使用了多个搜索引擎，包括 PubMed、GoogleScholar 和 ScienceDirect，搜索词为“大豆苷元” 、“大豆苷元治疗潜力”或个体效应。该研究包括所有同行评审的文章。不过，优先考虑最新发表的文章。大豆苷元不仅对乳腺癌、前列腺癌等恶性疾病具有保护作用，而且对糖尿病、骨质疏松症、心血管疾病等非恶性疾病也具有保护作用。大豆苷元激活多种信号通路，导致细胞周期停滞和细胞凋亡，以及恶性细胞中的抗氧化和抗转移作用。此外，针对不同癌细胞的抗癌作用也更加突出并进行了详细讨论。 总之，大豆苷元是一种有前途的药物开发化合物。大豆苷元通过各种分子机制的综合潜在抗癌活性及其治疗/临床状态需要进一步详细研究。版权所有 © 2024。由 Elsevier GmbH 出版。

Cancer is one of the leading causes of death and a great threat to people around the world. Cancer treatment modalities include surgery, radiotherapy, chemotherapy, radiochemotherapy, hormone therapy, and immunotherapy. The best approach is to use a combination of several types. Among the treatment methods mentioned above, chemotherapy is frequently used, but its activity is hampered by the development of drug resistance and many side effects. In this regard, the use of medicinal plants has been discussed, and in recent decades, the use of isolated phytochemicals came into the focus of interest. By critically evaluating the available evidence and emphasizing the unique perspective offered by this review, we provide insights into the potential of daidzein as a promising therapeutic agent, as well as outline future research directions to optimize its efficacy in clinical settings.To summarized the therapeutic potential of daidzein, an isoflavone phytoestrogen in the management of several human diseases with the focuses on the current status and future prospects as a therapeutic agent.Several search engines, including PubMed, GoogleScholar, and ScienceDirect, were used, with the search terms "daidzein", "daidzein therapeutic potential", or individual effects. The study included all peer-reviewed articles. However, the most recent publications were given priority.Daidzein showed protective effects against malignant diseases such as breast cancer, prostate cancer but also non-malignant diseases such as diabetes, osteoporosis, and cardiovascular diseases. Daidzein activates multiple signaling pathways leading to cell cycle arrest and apoptosis as well as antioxidant and anti-metastatic effects in malignant cells. Moreover, the anticancer effects against different cancer cells were more prominent and discussed in detail.In short, daidzein represents a promising compound for drug development. The comprehensive potential anticancer activities of daidzein through various molecular mechanisms and its therapeutic/clinical status required further detail studies.Copyright © 2024. Published by Elsevier GmbH.