癌症儿童的父母面临着生物、心理、社会和精神方面的担忧，这可能会显着降低生活质量 (QoL)。我们研究了综合肿瘤学 (IO) 干预对儿科血液肿瘤科儿童家长与生活质量相关问题的影响。该研究是前瞻性、对照、非随机和患者偏好的。最近（≤ 6 周）被诊断患有癌症的儿童的父母使用测量自己的担忧和健康 (MYCaW)、埃德蒙顿症状评估量表 (ESAS) 和欧洲癌症研究和治疗组织生活质量问卷 (EORTC QLQ- C30）。提供了 IO 咨询，包括日常放松呼吸和手法治疗的培训以及草药指导。三周后对两组家长进行重新评估。在同意参与的 68 名家长中，37 名（54%）接受了干预，其中 31 名作为对照。多变量分析发现IO干预组中希伯来语使用者较多（OR=5.96，95% CI=1.3-27.3，P=0.022）；女性（OR=5.23，95% CI=1.1-24.8，P=0.038）；与对照组相比，ESAS 报告疼痛（OR=1.2，95% CI=1.0-1.4，p=0.045）和食欲受损（OR=1.23，95% CI=1.01-1.48，p=0.034）。仅干预组在 EORTC 上的身体功能 (p<0.001)、认知功能 (0=0.018) 和疲劳 (p<0.001) 方面的基线至 3 周评分有所增加；以及 ESAS 食欲（p<0.001）和焦虑（p=0.02）。 ESAS 睡眠仅在对照组中有所增加 (p=0.029)。儿科血液肿瘤学中的 IO 干预措施解决家长中与生活质量相关的问题是可行的，可能主要增加身体症状和功能。需要进一步的研究来确认这些“真实世界”的临床结果，以及 IO 在“照顾护理者”中的作用。版权所有 © 2024。由 Elsevier Inc. 出版。

Parents of children with cancer face bio-psycho-social-spiritual concerns which can significantly reduce quality of life (QoL). We examined the impact of an integrative oncology (IO) intervention on QoL-related concerns among parents of children in a pediatric hematology-oncology department.The study was prospective, controlled, non-randomized and patient-preferenced. Parents of children recently (≤ 6 weeks) diagnosed with cancer were assessed using the Measure Yourself Concerns and Wellbeing (MYCaW), Edmonton Symptom Assessment Scale (ESAS) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). An IO consultation was provided, with training in daily relaxation-breathing and manual treatments, and guidance on herbal medicine. Parents in both groups were re-assessed after three weeks.Of 68 parents consenting to participate, 37 (54%) underwent the intervention with 31 serving as controls. Multivariate analysis found the IO intervention group to contain more Hebrew-speakers (OR=5.96, 95% CI=1.3-27.3, P=0.022); females (OR=5.23, 95% CI=1.1-24.8, P=0.038); and report pain (OR=1.2, 95% CI=1.0-1.4, p=0.045) and impaired appetite on ESAS (OR=1.23, 95% CI=1.01-1.48, p=0.034) when compared to controls. Only the intervention group showed increased baseline-to-3-week scores for physical functioning (p<0.001), cognitive functioning (0=0.018) and fatigue on EORTC (p<0.001); and for ESAS appetite (p<0.001) and anxiety (p=0.02). ESAS sleep increased only in controls (p=0.029).IO interventions in pediatric hematology-oncology addressing QoL-related concerns among parents are feasible, potentially increasing predominantly physical symptoms and functioning. Further research is needed to confirm these "real-world" clinical outcomes, and the role of IO in "Caring for the Caregiver".Copyright © 2024. Published by Elsevier Inc.