基于3D打印的生物高分子/黑磷纳米支架用于骨植入物：综述
3D printed biopolymer/black phosphorus nanoscaffolds for bone implants: A review
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影响因子:8.5
分区:生物学2区 Top / 生化与分子生物学2区 应用化学2区 高分子科学2区
发表日期:2024 Nov
作者:
Nannan Wu, Jinghong Li, Xinyu Li, Ran Wang, Lexin Zhang, Zhiwei Liu, Tifeng Jiao
DOI:
10.1016/j.ijbiomac.2024.135227
摘要
骨植入是治疗骨缺损的一种公认且有效的方法，但骨质疏松症和骨肿瘤相关的骨异常存在感染易感、愈合困难和疗效差等问题，给临床医学带来巨大挑战。3D打印技术可以实现三维物体的打印。研究人员通过逐层添加材料，制造出所需形状的三维结构。该技术广泛应用于骨缺损的修复，并作为一种创新的增材制造技术，具有未来潜在应用。本综述旨在总结近年来关于3D打印生物高分子材料的研究报告，介绍黑磷复合生物高分子材料用于3D打印骨植入物的最新研究进展，并总结复合材料的表征方法。还将介绍基于墨水打印和激光打印的3D打印方法，指出其特性和优势，并提出黑磷材料的光热治疗与骨再生材料的结合策略。最后，探讨骨植入材料与免疫细胞、生物环境的关系及3D打印骨植入物的未来前景。
Abstract
Bone implantation is one of the recognized and effective means of treating bone defects, but osteoporosis and bone tumor-related bone abnormalities have a series of problems such as susceptibility to infection, difficulty in healing, and poor therapeutic effect, which poses a great challenge to clinical medicine. Three-dimensional things may be printed using 3D printing. Researchers can feed materials through the printer layer by layer to create the desired shape for a 3D structure. It is widely employed in the healing of bone defects, and it is an improved form of additive manufacturing technology with prospective future applications. This review's objective is to provide an overview of the findings reports pertaining to 3D printing biopolymers in recent years, provide an overview of biopolymer materials and their composites with black phosphorus for 3D printing bone implants, and the characterization methods of composite materials are also summarized. In addition, summarizes 3D printing methods based on ink printing and laser printing, pointing out their special features and advantages, and provide a combination strategy of photothermal therapy and bone regeneration materials for black phosphorus-based materials. Finally, the associations between bone implant materials and immune cells, the bio-environment, as well as the 3D printing bone implants prospects are outlined.