3D打印的生物聚合物/黑色磷纳米骨植入物：综述
3D printed biopolymer/black phosphorus nanoscaffolds for bone implants: A review
影响因子:8.50000
分区:生物学2区 Top / 生化与分子生物学2区 应用化学2区 高分子科学2区
发表日期:2024 Nov
作者:
Nannan Wu, Jinghong Li, Xinyu Li, Ran Wang, Lexin Zhang, Zhiwei Liu, Tifeng Jiao
摘要
骨植入是治疗骨缺损的公认和有效手段之一，但是骨质疏松症和与骨肿瘤相关的骨异常具有一系列问题，例如感染，治愈难度和治疗作用不良，对临床药物构成了巨大挑战。可以使用3D打印打印三维事物。研究人员可以逐层通过打印机喂食材料，以为3D结构创建所需的形状。它广泛用于骨缺陷的治愈，它是一种具有预期的未来应用的增材制造技术的改进形式。本评论的目的是概述近年来与3D打印生物聚合物有关的发现报告，概述了生物聚合物材料及其复合材料，其复合材料与黑色磷一起用于3D打印骨植入物，并总结了复合材料的表征方法。此外，总结了基于墨水打印和激光打印的3D打印方法，指出了它们的特殊功能和优势，并为基于黑磷的材料提供了光热疗法和骨再生材料的组合策略。最后，概述了骨植入物材料与免疫细胞，生物环境以及3D印刷骨植入物的前景之间的关联。
Abstract
Bone implantation is one of the recognized and effective means of treating bone defects, but osteoporosis and bone tumor-related bone abnormalities have a series of problems such as susceptibility to infection, difficulty in healing, and poor therapeutic effect, which poses a great challenge to clinical medicine. Three-dimensional things may be printed using 3D printing. Researchers can feed materials through the printer layer by layer to create the desired shape for a 3D structure. It is widely employed in the healing of bone defects, and it is an improved form of additive manufacturing technology with prospective future applications. This review's objective is to provide an overview of the findings reports pertaining to 3D printing biopolymers in recent years, provide an overview of biopolymer materials and their composites with black phosphorus for 3D printing bone implants, and the characterization methods of composite materials are also summarized. In addition, summarizes 3D printing methods based on ink printing and laser printing, pointing out their special features and advantages, and provide a combination strategy of photothermal therapy and bone regeneration materials for black phosphorus-based materials. Finally, the associations between bone implant materials and immune cells, the bio-environment, as well as the 3D printing bone implants prospects are outlined.