肝癌是癌症死亡的第三大原因，发病率高，治疗效果差。近年来，多糖因其高效、低毒、生物相容性好、来源广泛、成本低廉等优点，在抗肝癌研究领域受到越来越多的关注。多糖已被证明具有良好的抗肝癌活性。本文对多糖抗肝癌的途径和分子机制进行了详细综述。多糖通过阻断细胞周期、诱导细胞凋亡、调节免疫、抑制癌细胞转移、抑制肿瘤血管生成等发挥抗肝癌活性。多糖的一级结构和链构象对其抗肝癌活性有重要影响。结构修饰增强了多糖的抗肝癌活性。多糖对化疗药物有良好的减毒和协同作用。多糖可作为功能载体构建靶向肝癌的智能纳米药物递送系统（DDS）。该综述可为多糖在抗肝癌领域的进一步开发和应用提供理论支持，并为食品、营养、医药等领域的相关研究人员提供理论参考和线索。版权所有©2024。出版者：Elsevier B.V.

Liver cancer is the third leading cause of cancer death, with high incidence and poor treatment effect. In recent years, polysaccharides have attracted more and more attention in the research field of anti-liver cancer because of their high efficiency, low toxicity, good biocompatibility, wide sources and low cost. Polysaccharides have been proven to have good anti-liver cancer activity. In this paper, the pathways and molecular mechanisms of polysaccharides against liver cancer were reviewed in detail. Polysaccharides exert anti-liver cancer activity by blocking cell cycle, inducing apoptosis, regulating immunity, inhibiting cancer cell metastasis, inhibiting tumor angiogenesis and so on. The primary structure and chain conformation of polysaccharides have an important influence on their anti-liver cancer activity. Structural modification enhanced the anti-liver cancer activity of polysaccharides. Polysaccharides have good attenuated and synergistic effects on chemotherapy drugs. Polysaccharides can be used as functional carriers to construct intelligent nano drug delivery systems (DDS) targeting liver cancer. This review can provide theoretical support for the further development and application of polysaccharides in the field of anti-liver cancer, and provide theoretical reference and clues for relevant researchers in food, nutrition, medicine and other fields.Copyright © 2024. Published by Elsevier B.V.