现在人们认识到，肿瘤不仅仅是大量转化细胞，而且与肿瘤微环境（TME）中的健康细胞错综复杂地相互关联，形成复杂且异质的结构。最近的研究发现，癌细胞可以从健康细胞中窃取线粒体来增强自身能力，同时降低其靶器官的功能。线粒体转移，即线粒体的细胞间运动，最近作为癌症生物学中的一个新过程出现，通过塑造肿瘤微环境的代谢景观，促进肿瘤生长、转移和对治疗的抵抗。这篇综述强调了转移的线粒体对癌症生物能学、氧化还原平衡和细胞凋亡抵抗的影响，这些因素共同促进了侵袭性癌症表型。此外，还讨论了线粒体转移的治疗意义，强调了针对这些途径克服耐药性和提高治疗效果的潜力。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

It is now recognized that tumors are not merely masses of transformed cells but are intricately interconnected with healthy cells in the tumor microenvironment (TME), forming complex and heterogeneous structures. Recent studies discovered that cancer cells can steal mitochondria from healthy cells to empower themselves, while reducing the functions of their target organ. Mitochondrial transfer, i.e. the intercellular movement of mitochondria, is recently emerging as a novel process in cancer biology, contributing to tumor growth, metastasis, and resistance to therapy by shaping the metabolic landscape of the tumor microenvironment. This review highlights the influence of transferred mitochondria on cancer bioenergetics, redox balance and apoptotic resistance, which collectively foster aggressive cancer phenotype. Furthermore, the therapeutic implications of mitochondrial transfer are discussed, emphasizing the potential of targeting these pathways to overcome drug resistance and improve treatment efficacy.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.