代谢肥胖（由体重指数 BMI 定义）表型与肥胖相关癌症 (ORC) 之间的性别差异仍然未知。考虑到 BMI 反映总体肥胖而非脂肪分布，我们旨在系统地评估我们新提出的代谢人体测量表型与按性别划分的总体和特定部位 ORC 风险之间的关联。 共有 141,579 名男性（平均年龄：56.37 岁，平均年龄：56.37 岁）随访时间：12.04年）和来自英国生物银行的131,047名女性（平均年龄：56.22岁，平均随访时间：11.82年）被纳入，并根据代谢状态（代谢健康/不健康）指定为代谢人体测量表型、BMI（非肥胖/肥胖）和体型（梨形/苗条/苹果形/宽形）。 使用 Cox 比例风险回归模型通过风险比 (HR) 和 95% 置信区间 (CI) 评估不同表型与总体和特定位点 ORC 的性别特异性关联。我们发现代谢不健康和/或肥胖表型传达了更高的与代谢健康的非肥胖表型相比，男性患 ORC 和结直肠癌的总体风险高于女性 (Pinteraction < 0.05)。值得注意的是，代谢健康的肥胖表型导致男性大多数 ORC 风险增加（HR：1.58 ~ 2.91），但仅与子宫内膜癌（HR = 1.89，95% CI：1.54-2.32）和绝经后乳腺癌的较高风险相关（女性 HR = 1.17，95% CI：1.05-1.31）。同样，即使在代谢健康的情况下，携带苹果形和宽形表型（代谢健康的苹果/宽形和代谢健康的非肥胖苹果/宽形）的男性患 ORC（主要是结直肠癌、肝癌、贲门癌和肾癌）的风险也增加，HRs ：1.20 ~ 3.81）与梨形身材或非肥胖梨形身材相比。代谢人体测量表型与ORC风险之间存在显着的性别差异。我们建议未来的兽人预防和控制应考虑体型和性别差异。© 2024。作者。

Sex disparity between metabolic-obesity (defined by body mass index, BMI) phenotypes and obesity-related cancer (ORC) remains unknown. Considering BMI reflecting overall obesity but not fat distribution, we aimed to systematically assess the association of our newly proposed metabolic-anthropometric phenotypes with risk of overall and site-specific ORC by sex.A total of 141,579 men (mean age: 56.37 years, mean follow-up time: 12.04 years) and 131,047 women (mean age: 56.22 years, mean follow up time: 11.82 years) from the UK Biobank was included, and designated as metabolic-anthropometric phenotypes based on metabolic status (metabolically healthy/unhealthy), BMI (non-obesity/obesity) and body shape (pear/slim/apple/wide). The sex-specific association of different phenotypes with overall and site-specific ORC was assessed by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models.We found metabolically unhealthy and/or obesity phenotypes conveyed a higher risk in men than in women for overall ORC and colorectal cancer compared with metabolically healthy non-obesity phenotype (Pinteraction < 0.05). Of note, metabolically healthy obesity phenotype contributed to increased risks of most ORC in men (HRs: 1.58 ~ 2.91), but only correlated with higher risks of endometrial (HR = 1.89, 95% CI: 1.54-2.32) and postmenopausal breast cancers (HR = 1.17, 95% CI: 1.05-1.31) in women. Similarly, even under metabolically healthy, men carrying apple and wide shapes phenotypes (metabolically healthy apple/wide and metabolically healthy non-obesity apple/wide) suffered an increased risk of ORC (mainly colorectal, liver, gastric cardia, and renal cancers, HRs: 1.20 ~ 3.81) in comparison with pear shape or non-obesity pear shape.There was a significant sex disparity between metabolic-anthropometric phenotypes and ORC risk. We advised future ORC prevention and control worth taking body shape and sex disparity into account.© 2024. The Author(s).