铁死亡是一种新形式的程序性细胞死亡，是由于脂质过氧化物因各种刺激（如高水平的铁、氧化应激、代谢紊乱等）而积累而导致脂质膜受损而引起的。糖、脂质、氨基酸、铁代谢对于调节铁死亡至关重要。溶质载体转运蛋白（SLC）家族被称为细胞的“代谢门控”，负责运输细胞内的营养物质和代谢物。最近的研究强调了 SLC 家族成员通过控制各种营养物质的运输在铁死亡中发挥的重要作用。在此，我们总结了SLC在离子、营养物质代谢控制和多种信号通路调控的铁死亡中的功能和机制，重点关注SLC相关转运蛋白，其主要转运五种重要成分：葡萄糖、氨基酸、脂质、微量金属离子和其他离子。此外，还讨论了用铁死亡诱导剂靶向 SLC 对包括肿瘤在内的各种疾病的潜在临床应用。总体而言，本文深入探讨了 SLC 家族在铁死亡中的新作用，旨在增强我们对铁死亡调节机制的理解，并确定临床应用的新治疗靶点。© 2024。作者。

Ferroptosis is a novel form of programmed cell death caused by damage to lipid membranes due to the accumulation of lipid peroxides in response to various stimuli, such as high levels of iron, oxidative stress, metabolic disturbance, etc. Sugar, lipid, amino acid, and iron metabolism are crucial in regulating ferroptosis. The solute carrier transporters (SLCs) family, known as the "metabolic gating" of cells, is responsible for transporting intracellular nutrients and metabolites. Recent studies have highlighted the significant role of SLCs family members in ferroptosis by controlling the transport of various nutrients. Here, we summarized the function and mechanism of SLCs in ferroptosis regulated by ion, metabolic control of nutrients, and multiple signaling pathways, with a focus on SLC-related transporters that primarily transport five significant components: glucose, amino acid, lipid, trace metal ion, and other ion. Furthermore, the potential clinical applications of targeting SLCs with ferroptosis inducers for various diseases, including tumors, are discussed. Overall, this paper delves into the novel roles of the SLCs family in ferroptosis, aiming to enhance our understanding of the regulatory mechanisms of ferroptosis and identify new therapeutic targets for clinical applications.© 2024. The Author(s).