随着人口老龄化，脑癌和神经退行性疾病的发病率不断增加。在胶质母细胞瘤和阿尔茨海默病（AD）之间观察到了生物学上的相似之处，它们都会加速大脑老化。在这里，我们的目的是绘制胶质母细胞瘤患者肿瘤邻近皮质中 AD 神经病理改变 (ADNC) 的共存情况。 AD 标志物β淀粉样蛋白 (Abeta)、淀粉样前体蛋白 (APP) 和过度磷酸化 tau (pTau) 的免疫组织化学筛查对 205 名患者的 420 个肿瘤样本进行了研究。对于每个皮质区域，我们对 ADNC、神经元、肿瘤细胞和小胶质细胞进行了量化。52% 的患者 (N = 106/205) 在肿瘤邻近皮质中显示 ADNC（Abeta 和 pTau、Abeta 或 pTau），组织学结果显示模式与 AD 广泛一致。 ADNC 与患者年龄呈正相关，并根据 Thal 期和 Braak 期在空间上变化。它随着肿瘤细胞浸润的增加而降低 (P < .0001)，并且与神经元细胞体 (N = 182/205) 和肿瘤坏死相关轴突球体 (N = 195/205；P = ) 中 APP 的频繁表达无关。 46）。小胶质细胞反应主要存在于肿瘤细胞浸润和 ADNC 中，并受到患者年龄和性别的进一步调节。 ADNC 不会影响当前队列中患者的生存。我们的研究结果强调 ADNC 在胶质母细胞瘤附近频繁出现，这与患者年龄和肿瘤位置有关。 AD和胶质母细胞瘤的同时发生似乎是随机的，没有明确的空间关系。 ADNC 不会影响我们队列中患者的生存。© 作者 2024。由牛津大学出版社、神经肿瘤学会和欧洲神经肿瘤学会出版。

The incidence of brain cancer and neurodegenerative diseases is increasing with a demographic shift towards aging populations. Biological parallels have been observed between glioblastoma and Alzheimer's disease (AD), which converge on accelerated brain aging. Here, we aimed to map the cooccurrence of AD neuropathological change (ADNC) in the tumor-adjacent cortex of patients with glioblastoma.Immunohistochemical screening of AD markers amyloid beta (Abeta), amyloid precursor protein (APP), and hyperphosphorylated tau (pTau) was conducted in 420 tumor samples of 205 patients. For each cortex area, we quantified ADNC, neurons, tumor cells, and microglia.Fifty-two percent of patients (N = 106/205) showed ADNC (Abeta and pTau, Abeta or pTau) in the tumor-adjacent cortex, with histological patterns widely consistent with AD. ADNC was positively correlated with patient age and varied spatially according to Thal phases and Braak stages. It decreased with increasing tumor cell infiltration (P < .0001) and was independent of frequent expression of APP in neuronal cell bodies (N = 182/205) and in tumor necrosis-related axonal spheroids (N = 195/205; P = .46). Microglia response was most present in tumor cell infiltration plus ADNC, being further modulated by patient age and sex. ADNC did not impact patient survival in the present cohort.Our findings highlight the frequent presence of ADNC in the glioblastoma vicinity, which was linked to patient age and tumor location. The cooccurrence of AD and glioblastoma seemed stochastic without clear spatial relation. ADNC did not impact patient survival in our cohort.© The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.