在中国东部，多个痕量元素与胃癌病变和胃癌的尿液浓度与胃癌之间的关联分析
Association analyses between urinary concentrations of multiple trace elements and gastric precancerous lesions and gastric cancer in Anhui province, eastern China
影响因子:3.40000
分区:医学3区 / 公共卫生3区
发表日期:2024
作者:
Shiqing Qian, Fang Xu, Min Wang, Meng Zhang, Shaopeng Ding, Guoqing Jin, Xiaohui Zhang, Wenli Cheng, Li Wang, Yuting Zhu, Wuqi Wang, Princess Ofosuhemaa, Tingting Wang, Xiao Lin, Yu Zhu, Yaning Lv, Anla Hu, Wanshui Yang, Gengsheng He, Qihong Zhao
摘要
有限的流行病学证据表明，对痕量元素的暴露会对胃癌性病变（GPL）和胃癌（GC）的发展产生不利影响。这项研究旨在估算从2021年3月至2022年12月在Anhui省进行了多个元素与GPL和GC的多个元素的关联。总共528名受试者（从1,020名GPL，20020例GC，200例GC患者和762例正常对照者中随机采样）。铁（Fe），铜（CU），锌（Zn），镍（Ni），锶（SR）和剖宫产（CS）的尿液水平使用电感耦合等离子体质谱法（ICP-MS）测量。采用了四种不同的统计方法来探索与混合接触的GPL和GC的风险，包括多元逻辑回归，加权分位数回归（WQS），分位数G-Componton（QGCOMP）（QGCOMP）（QGCOMP）和贝叶斯内核机器回归（BKMR）模型。WQS模型与尿液中的混合元素有关，使得与g的混合物相处均可构成的元素。 GPL的混合物暴露为1.34（95％CI：1.34-1.61），GC的混合物暴露为1.38（95％CI：1.27-1.50）。 QGCOMP和BKMR模型还证明了混合物与GPL和GC之间存在统计学上显着的正相关性。考虑病例对照研究的局限性，未来的前瞻性研究有必要阐明痕量元素暴露对人类健康的综合效果和机制。
Abstract
Limited epidemiological evidence suggests that exposure to trace elements adversely impacts the development of gastric precancerous lesions (GPL) and gastric cancer (GC). This study aimed to estimate the association of individual urinary exposure to multiple elements with GPL and GC.A case-control investigation was conducted in Anhui Province from March 2021 to December 2022. A total of 528 subjects (randomly sampled from 1,020 patients with GPL, 200 patients with GC, and 762 normal controls) were included in our study. Urinary levels of iron (Fe), copper (Cu), zinc (Zn), nickel (Ni), strontium (Sr), and Cesium (Cs) were measured using inductively coupled plasma mass spectrometry (ICP-MS). Four different statistical approaches were employed to explore the risk of GPL and GC with mixed exposure, including multivariate logistic regression, weighted quantile regression (WQS), quantile g-computation (Qgcomp), and the Bayesian kernel machine regression (BKMR) model.The WQS model indicated that urinary exposure to a mixture of elements is positively correlated with both GPL and GC, with ORs for the mixture exposure of 1.34 (95% CI: 1.34-1.61) for GPL and 1.38 (95% CI: 1.27-1.50) for GC. The Qgcomp and BKMR models also demonstrated a statistically significant positive correlation between the mixture and both GPL and GC.Considering the limitations of case-control studies, future prospective studies are warranted to elucidate the combined effects and mechanisms of trace elements exposure on human health.