蛋白质酪氨酸磷酸化是一种翻译后修饰，可调节蛋白质结构以调节流行生物的体内平衡和功能。这一生理过程由两个酶家族调节：蛋白酪氨酸激酶（PTK）和蛋白酪氨酸磷酸酶（PTP）。作为蛋白质功能的重要调节因子，PTP对于维持不同系统的细胞内在生理以及肝脏的生理和病理过程是不可或缺的。 PTP 失调与多种肝脏相关疾病有关，包括慢性肝病 (CLD)、肝细胞癌 (HCC) 和肝损伤，并且一些 PTP 正在作为药物治疗靶点进行研究。因此，考虑到 PTP 在多种肝脏疾病中的调节作用，有必要对其功能和机制进行整理综述。此外，根据目前靶向治疗的研究现状，我们强调纳入几位在肝病发生和进展中具有临床意义的PTP成员。作为肝脏疾病治疗的新兴突破方向，本文综述了PTP靶向化合物在肝脏疾病中的研究现状，阐明其在临床治疗中的潜力。总体而言，本综述旨在支持开发基于 PTP 的新型肝病治疗途径。© 2024 作者。

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms' homeostasis and function. This physiological process is regulated by two enzyme families, protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). As an important regulator of protein function, PTPs are indispensable for maintaining cell intrinsic physiology in different systems, as well as liver physiological and pathological processes. Dysregulation of PTPs has been implicated in multiple liver-related diseases, including chronic liver diseases (CLDs), hepatocellular carcinoma (HCC), and liver injury, and several PTPs are being studied as drug therapeutic targets. Therefore, given the regulatory role of PTPs in diverse liver diseases, a collated review of their function and mechanism is necessary. Moreover, based on the current research status of targeted therapy, we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver diseases. As an emerging breakthrough direction in the treatment of liver diseases, this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical treatment. Overall, this review aims to support the development of novel PTP-based treatment pathways for liver diseases.© 2024 The Authors.