促生蛋白：纤维化疾病的有前途的生物标志物和治疗靶标
Progranulin: A promising biomarker and therapeutic target for fibrotic diseases
影响因子:14.60000
分区:医学1区 Top / 药学1区
发表日期:2024 Aug
作者:
Fan Yang, Ming-Han Cheng, Hai-Feng Pan, Jian Gao
摘要
促生蛋白（PGRN）是一种由多种细胞类型表达的多功能生长因子样蛋白，在纤维化疾病的生理和病理学过程中起重要功能，包括伤口愈合和炎症反应。发现PGRN通过与与TNF受体结合的肿瘤坏死因子-Alpha（TNF-α）竞争来抑制促炎作用。值得注意的是，炎症发育中的组织修复过多会导致组织纤维化。先前的研究表明，PGRN在调节炎症反应中的重要性。最近，多项研究表明，PGRN与纤维发生有关，并被认为可以监测包括肝脏，心血管，肺和皮肤在内的多个器官中纤维化的形成。本文是一项全面的评论，总结了我们当前对PGRN的了解，从发现到纤维化的作用。接下来是对PGRN的特征的深入研究，包括其结构，基本功能和细胞内信号传导。最后，我们将讨论PGRN在纤维化诊断和治疗中的潜力。
Abstract
Progranulin (PGRN), a multifunctional growth factor-like protein expressed by a variety of cell types, serves an important function in the physiologic and pathologic processes of fibrotic diseases, including wound healing and the inflammatory response. PGRN was discovered to inhibit pro-inflammation effect by competing with tumor necrosis factor-alpha (TNF-α) binding to TNF receptors. Notably, excessive tissue repair in the development of inflammation causes tissue fibrosis. Previous investigations have indicated the significance of PGRN in regulating inflammatory responses. Recently, multiple studies have shown that PGRN was linked to fibrogenesis, and was considered to monitor the formation of fibrosis in multiple organs, including liver, cardiovascular, lung and skin. This paper is a comprehensive review summarizing our current knowledge of PGRN, from its discovery to the role in fibrosis. This is followed by an in-depth look at the characteristics of PGRN, consisting of its structure, basic function and intracellular signaling. Finally, we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.