颗粒体蛋白前体 (PGRN) 是一种由多种细胞类型表达的多功能生长因子样蛋白，在纤维化疾病的生理和病理过程中发挥重要作用，包括伤口愈合和炎症反应。人们发现 PGRN 通过与肿瘤坏死因子-α (TNF-α) 竞争与 TNF 受体的结合来抑制促炎症作用。值得注意的是，炎症发展过程中的过度组织修复会导致组织纤维化。先前的研究表明 PGRN 在调节炎症反应中的重要性。最近，多项研究表明PGRN与纤维化有关，并被认为可以监测多个器官纤维化的形成，包括肝脏、心血管、肺和皮肤。本文是一篇全面的综述，总结了我们目前对 PGRN 的了解，从它的发现到在纤维化中的作用。接下来深入研究 PGRN 的特征，包括其结构、基本功能和细胞内信号传导。最后，我们将讨论 PGRN 在纤维化诊断和治疗中的潜力。© 2024 作者。

Progranulin (PGRN), a multifunctional growth factor-like protein expressed by a variety of cell types, serves an important function in the physiologic and pathologic processes of fibrotic diseases, including wound healing and the inflammatory response. PGRN was discovered to inhibit pro-inflammation effect by competing with tumor necrosis factor-alpha (TNF-α) binding to TNF receptors. Notably, excessive tissue repair in the development of inflammation causes tissue fibrosis. Previous investigations have indicated the significance of PGRN in regulating inflammatory responses. Recently, multiple studies have shown that PGRN was linked to fibrogenesis, and was considered to monitor the formation of fibrosis in multiple organs, including liver, cardiovascular, lung and skin. This paper is a comprehensive review summarizing our current knowledge of PGRN, from its discovery to the role in fibrosis. This is followed by an in-depth look at the characteristics of PGRN, consisting of its structure, basic function and intracellular signaling. Finally, we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.© 2024 The Authors.