前花糖蛋白：纤维化疾病的潜在生物标志物与治疗靶点
Progranulin: A promising biomarker and therapeutic target for fibrotic diseases
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影响因子:14.6
分区:医学1区 Top / 药学1区
发表日期:2024 Aug
作者:
Fan Yang, Ming-Han Cheng, Hai-Feng Pan, Jian Gao
DOI:
10.1016/j.apsb.2024.04.026
摘要
前花糖蛋白（PGRN）是一种多功能生长因子样蛋白，由多种细胞类型表达，在纤维化疾病的生理和病理过程中发挥重要作用，包括伤口愈合和炎症反应。研究发现，PGRN通过与肿瘤坏死因子α（TNF-α）竞争与其受体结合，从而抑制促炎作用。值得注意的是，过度的组织修复在炎症发展中引起组织纤维化。先前研究表明，PGRN在调控炎症反应中具有重要意义。近年来的多项研究显示，PGRN与纤维形成有关，被认为能监测包括肝脏、心血管、肺和皮肤在内的多器官纤维化的发生。本综述系统总结了PGRN的发现、结构、基本功能和细胞内信号机制，最后讨论PGRN在纤维化的诊断与治疗中的潜力。
Abstract
Progranulin (PGRN), a multifunctional growth factor-like protein expressed by a variety of cell types, serves an important function in the physiologic and pathologic processes of fibrotic diseases, including wound healing and the inflammatory response. PGRN was discovered to inhibit pro-inflammation effect by competing with tumor necrosis factor-alpha (TNF-α) binding to TNF receptors. Notably, excessive tissue repair in the development of inflammation causes tissue fibrosis. Previous investigations have indicated the significance of PGRN in regulating inflammatory responses. Recently, multiple studies have shown that PGRN was linked to fibrogenesis, and was considered to monitor the formation of fibrosis in multiple organs, including liver, cardiovascular, lung and skin. This paper is a comprehensive review summarizing our current knowledge of PGRN, from its discovery to the role in fibrosis. This is followed by an in-depth look at the characteristics of PGRN, consisting of its structure, basic function and intracellular signaling. Finally, we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.