肿瘤免疫疗法的当代进展巩固了其作为抗癌有效方法的作用。尽管如此，肿瘤微环境中普遍存在的“免疫冷”状态对其功效构成了重大障碍。为了解决这个问题，焦亡——一种由gasdermin介导的程序性细胞死亡，其特征在于其炎症特征——成为一种关键机制。它催化大量促炎细胞因子和免疫原的释放，有可能将免疫抑制性“冷”肿瘤转化为反应性“热”肿瘤。在此，我们将首先概述细胞焦亡作为一种独特的细胞死亡形式及其分子机制。随后，我们将重点介绍焦亡激活剂在肿瘤免疫治疗领域的应用。从焦亡激活剂在肿瘤免疫治疗中的应用中获得的见解可能会导致安全有效的焦亡激活剂的开发，从而显着丰富肿瘤免疫治疗的武器库。© 2024 作者。

Contemporary progress in tumor immunotherapy has solidified its role as an effective approach in combating cancer. Nonetheless, the prevalent "immune cold" state within the tumor microenvironment poses a substantial barrier to its efficacy. Addressing this, pyroptosis-a gasdermin-mediated programmed cell death characterized by its inflammatory profile-emerges as a crucial mechanism. It catalyzes the release of vast quantities of pro-inflammatory cytokines and immunogens, potentially transforming immunosuppressive "cold" tumors into reactive "hot" ones. Herein, we will initially present an overview of pyroptosis as a distinct form of cell death, along with its molecular mechanisms. Subsequently, we will focus on introducing how pyroptosis activators are utilized in the field of tumor immunotherapy. Insights gained from applications of pyroptosis activators in tumor immunotherapy could lead to the development of safe and efficient pyroptosis activators, significantly enriching the arsenal for tumor immunotherapy.© 2024 The Authors.