NK细胞的基础生物学及其在肿瘤免疫治疗中的应用。
The basic biology of NK cells and its application in tumor immunotherapy.
发表日期：2024
作者：
Pan Jiang, Shaoze Jing, Gaohong Sheng, Fajing Jia
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
自然杀伤（NK）细胞作为肿瘤免疫微环境中的效应细胞发挥着至关重要的作用，能够通过表达识别肿瘤相关配体的多种激活和抑制受体来识别和消除肿瘤细胞。因此，利用 NK 细胞进行治疗是基于 T 细胞的肿瘤免疫治疗策略的重要辅助手段。目前，基于NK细胞的肿瘤免疫治疗策略包括多种方法，包括过继性NK细胞疗法、细胞因子疗法、基于抗体的NK细胞疗法（增强NK细胞介导的ADCC、NK细胞接合剂、免疫检查点阻断疗法）以及纳米粒子的利用和小分子来调节 NK 细胞的抗肿瘤功能。本文全面概述了基于 NK 细胞的抗肿瘤免疫治疗的最新进展，旨在为癌症患者的临床治疗提供见解和方法。版权所有 © 2024 Jiang、Jing、Sheng、Jia。
Natural Killer (NK) cells play a crucial role as effector cells within the tumor immune microenvironment, capable of identifying and eliminating tumor cells through the expression of diverse activating and inhibitory receptors that recognize tumor-related ligands. Therefore, harnessing NK cells for therapeutic purposes represents a significant adjunct to T cell-based tumor immunotherapy strategies. Presently, NK cell-based tumor immunotherapy strategies encompass various approaches, including adoptive NK cell therapy, cytokine therapy, antibody-based NK cell therapy (enhancing ADCC mediated by NK cells, NK cell engagers, immune checkpoint blockade therapy) and the utilization of nanoparticles and small molecules to modulate NK cell anti-tumor functionality. This article presents a comprehensive overview of the latest advances in NK cell-based anti-tumor immunotherapy, with the aim of offering insights and methodologies for the clinical treatment of cancer patients.Copyright © 2024 Jiang, Jing, Sheng and Jia.