通过系统回顾和荟萃分析，调查口腔鳞状细胞癌（OSCC）患者生物样本中的抗氧化酶状态，并与健康人的生物样本进行比较。抗氧化酶有过氧化氢酶（CAT）、钠歧化酶（SOD）和谷胱甘肽过氧化物 (GPx) 也包含在分析中。对 PubMed、Science Direct、Scopus、Web of Science 和 Wiley Online Library 数据库中发表的 1999 年 1 月至 2022 年 12 月期间发表的研究进行了文献检索。总共选择了 831 篇文章，其中 131 篇被发现相关。最终筛选并纳入12篇研究全文。评估其他抗氧化酶的研究被排除在外。使用综合荟萃分析 v3（Biostat，恩格尔伍德，新泽西州，美国）导出标准化平均差 (SMD) 以进行荟萃分析。使用具有 95% 置信区间 (CI) 的随机效应模型来估计效应大小。 P < 0.05 被认为是显着的。八项研究中测量了 CAT 水平（n

To investigate the antioxidant enzyme status in biological samples of patients with oral squamous cell carcinoma (OSCC) and compare them with biological samples of healthy people through a systematic review and meta-analysis.Antioxidant enzymes of catalase (CAT), sodium dismutase (SOD) and glutathione peroxide (GPx) were included in the analysis. A literature search was conducted of the PubMed, Science Direct, Scopus, Web of Science and Wiley Online Library databases for studies published between January 1999 and December 2022. A total of 831 articles were selected, of which 131 were found to be relevant. Finally, the full texts of 12 studies were screened and included. Studies that evaluated other antioxidant enzymes were excluded. Standardised mean difference (SMD) was derived to conduct a meta-analysis using comprehensive meta-analysis v3 (Biostat, Englewood, NJ, USA). A random effects model with 95% confidence interval (CI) was used to estimate the effect size. P < 0.05 was considered significant.CAT levels were measured in eight studies (n = 567) and the mean values for the OSCC and control groups were 4.81 ± 2.57 and 10.02 ± 1.81, respectively (SMD 3.18, 95% CI 1.01 to 1.42; P = 0.001). SOD level was evaluated in 11 studies (n = 762) and the values for the OSCC and control groups were 3.78 ± 1.45 and 7.34 ± 1.79, respectively (SMD 3.66, 95% CI 1.51 to 1.94; P = 0.001). GPx level was evaluated in 10 studies (n = 697) and the values for the OSCC and control groups were 13.33 ± 1.42 and 16.54 ± 2.9, respectively (SMD 1.91, 95% CI 1.34 to 1.77; P = 0.001). The heterogeneity between the studies was severe (I2 ≥ 90%). The risk of bias between studies was low to moderate.Analysis revealed that the levels of antioxidant enzymes decreased in biological samples of patients with OSSC as compared to healthy controls. Understanding the pathological progress of OSCC by analysing the level of antioxidant enzymes is beneficial in formulating a personalised, targeted pro-oxidant therapy for cancer treatment.