2017 年，国际癌症研究机构重新评估了苯的致癌性，工作组重申苯与非霍奇金淋巴瘤 (NHL) 存在积极但不确定的关联。为了扩展我们之前对上海人群队列中中国女性累积职业苯暴露和 NHL 风险的显着暴露反应的观察，我们延长了对该队列的随访，并将数据与类似设计的基于人群的数据汇总。上海的一群男人。通过将顺序工作暴露矩阵强度评级与来自上海工厂检查数据库的定量苯测量值相结合，得出了汇总分析中 134,449 名参与者的累积暴露估计值。使用 Cox 比例风险模型评估苯暴露指标与 NHL（n = 363 例，包括多发性骨髓瘤 [MM]）之间的关联。汇总人群中曾经职业性接触苯与 NHL 风险相关（HR = 1.5，95% CI = 1.2-2.0），并且观察到随着持续时间（ptrend = .003）和累积暴露（ptrend =）的增加，暴露-反应关系.003）。对于病例定义中伴或不伴 MM 的 NHL，与曾经暴露、持续时间和累积暴露的关联相似，包括最高四分位数的终生累积暴露（HR = 1.6，95% CI = 1.1-2.4，包括 MM；HR = 1.7） , 95% CI = 1.1-2.7（排除 MM）。汇总分析表明慢性淋巴细胞白血病亚型的风险升高（曾经暴露与从未暴露的 HR = 2.3，95% CI = 0.9-5.6）。这些观察结果为职业苯暴露与 NHL 风险之间的合理关联提供了额外的支持。© 2024 作者。约翰·威利出版的《国际癌症杂志》

The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non-Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure-response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population-based cohort in Shanghai, we extended follow-up of this cohort and pooled the data with a similarly designed population-based cohort of men in Shanghai. Cumulative exposure estimates were derived for 134,449 participants in the pooled analysis by combining ordinal job-exposure matrix intensity ratings with quantitative benzene measurements from an inspection database of Shanghai factories. Associations between benzene exposure metrics and NHL (n = 363 cases including multiple myeloma [MM]) were assessed using Cox proportional hazard models. Ever occupational exposure to benzene in the pooled population was associated with NHL risk (HR = 1.5, 95% CI = 1.2-2.0), and exposure-response relationships were observed for increasing duration (ptrend = .003) and cumulative exposure (ptrend = .003). Associations with ever exposure, duration, and cumulative exposure were similar for NHL with and without MM in the case definition, including lifetime cumulative exposures in the highest quartile (HR = 1.6, 95% CI = 1.1-2.4 with MM included; HR = 1.7, 95% CI = 1.1-2.7 with MM excluded). An elevated risk of the chronic lymphocytic leukemia subtype was suggested in the pooled analyses (HR for ever vs. never exposure = 2.3, 95% CI = 0.9-5.6). These observations provide additional support for a plausible association between occupational benzene exposure and risk of NHL.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.