脑肿瘤和转移灶脑出血的临床和影像学表现:综合概述。
Clinical and imaging manifestations of intracerebral hemorrhage in brain tumors and metastatic lesions: a comprehensive overview.
发表日期:2024 Sep 02
作者:
Semil Eminovic, Tobias Orth, Andrea Dell'Orco, Lukas Baumgärtner, Andrea Morotti, David Wasilewski, Melisa S Guelen, Michael Scheel, Tobias Penzkofer, Jawed Nawabi
来源:
Brain Structure & Function
摘要:
这项观察性研究旨在提供由于潜在转移 (mICH) 或脑肿瘤 (tICH) 病变引起的急性脑出血 (ICH) 的详细临床和影像学特征/检查。我们进行了一项回顾性、单中心研究,评估患者初次 CT 成像表现为隐匿性 ICH,根据 H 原子分类,后续 MRI 成像分为 tICH 或 mICH。回顾了人口统计学、临床和放射学数据。我们纳入了 116 名患者(tICH:20/116,17.24%;mICH:96/116,82.76%)。引起ICH的最常见恶性肿瘤是肺癌(27.59%)、恶性黑色素瘤(18.10%)和胶质母细胞瘤(10.34%)。观察到的三种最常见的中风样症状是局灶性缺陷(62/116,53.45%)、头晕(42/116,36.21%)和认知障碍(27/116,23.28%)。 mICH 患病率最高出现在枕叶 (mICH: 28.13%, tICH: 0.00%; p = 0.004),tICH 发生在胼胝体 (tICH: 10.00%, mICH: 0.00%; p = 0.029)。抗凝治疗仅在 mICH 患者中频繁出现(tICH:0.00%,mICH:5.21%;p = 0.586)。 tICH 患者中出血量(tICH:12682 mm3,mICH:5708 mm3,p = 0.020)和水肿量(tICH:49389 mm3,mICH:20972 mm3,p = 0.035)明显更大。超过一半的肿瘤性 ICH 患者表现出类似中风的症状。 mICH 中肺癌最常见,tICH 中胶质母细胞瘤最常见。虽然临床表现相似,但肿瘤位置和治疗的显着差异是明显的。© 2024。作者。
This observational study aims to provide a detailed clinical and imaging characterization/workup of acute intracerebral hemorrhage (ICH) due to either an underlying metastasis (mICH) or brain tumor (tICH) lesion.We conducted a retrospective, single-center study, evaluating patients presenting with occult ICH on initial CT imaging, classified as tICH or mICH on follow-up MRI imaging according to the H-Atomic classification. Demographic, clinical and radiological data were reviewed.We included 116 patients (tICH: 20/116, 17.24%; mICH: 96/116, 82.76%). The most common malignancies causing ICH were lung cancer (27.59%), malignant melanoma (18.10%) and glioblastoma (10.34%). The three most common stroke-like symptoms observed were focal deficit (62/116, 53.45%), dizziness (42/116, 36.21%) and cognitive impairment (27/116, 23.28%). Highest mICH prevalence was seen in the occipital lobe (mICH: 28.13%, tICH: 0.00%; p = 0.004) with tICH more in the corpus callosum (tICH: 10.00%, mICH: 0.00%; p = 0.029). Anticoagulation therapy was only frequent in mICH patients (tICH: 0.00%, mICH: 5.21%; p = 0.586). Hemorrhage (tICH: 12682 mm3, mICH: 5708 mm3, p = 0.020) and edema volumes (tICH: 49389 mm3, mICH: 20972 mm3, p = 0.035) were significantly larger within tICH patients.More than half of the patients with neoplastic ICH exhibited stroke-like symptoms. Lung cancer was most common in mICH, glioblastoma in tICH. While clinical presentations were similar, significant differences in tumor location and treatments were discernible.© 2024. The Author(s).