先进的疗法预计将在支持损伤后修复、阻止肌肉骨骼组织退化以实现和促进身体活动方面发挥关键作用。尽管取得了进步，但骨科先进疗法的开发进展仍落后于肿瘤学等专业，因为创新的再生治疗策略在肌肉骨骼临床试验中未达到预期。在进行临床试验之前，研究人员应重点了解所研究目标背后的作用机制。战略研究网络不仅需要加强志同道合的研究人员之间的科学交流，还需要包括早期的商业观点、公司和风险投资观点、监管见解和报销观点。只有在这种合作中，才能克服临床试验和接触患者的重要障碍。

Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue to enable and promote physical activity. Despite advancements, the progress in developing advanced therapies in orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short of their expectations in musculoskeletal clinical trials. Researchers should focus on understanding the mechanism of action behind the investigated target before conducting clinical trials. Strategic research networks are needed that not only enhance scientific exchange among like-minded researchers but need to include early on commercial views, companies and venture perspectives, regulatory insights and reimbursement perspectives. Only in such collaborations essential roadblocks towards clinical trials and go-to-patients be overcome.