本综述旨在调查经口激光显微手术声门上喉切除术 (TOLM-SGL) 治疗 cT1-T3 喉癌的手术、功能和肿瘤学结果。两位独立研究者检索了 PubMed、Scopus 和 Cochrane 图书馆，以查找调查手术、声门上喉切除术的研究。使用 PRISMA 语句的 TOLM-SGL 的功能和肿瘤学结果。对 MINORS 进行了偏倚分析。纳入了 24 项研究（937 名患者），其中 206 例（25.9%）cT1、467 例（58.7%）cT2 和 123 例（15.4%）cT3 病例。大多数患者为 cN0 (63.9%)。 TOLM 的平均住院时间为 10.1 天。误吸 (5.5%) 和出血 (5.3%) 是最常见的并发症。喉保存率为93.7%。 18.0% 的患者进行了临时气管切开术，平均拔管时间为 6.8 天。 59.9% 的患者体内放置了饲管。 6.4 天后重新开始口服饮食。 2.4% 的病例需要进行彻底的胃造口术。 5 年 OS 和 DFS 分别为 70.1% 和 82.0%。 4.6%、11.6% 和 5.1% 的患者发生远处转移、局部和区域复发。研究之间在纳入标准、患者概况、TOLM 适应症以及手术、功能和肿瘤结果细节方面存在重要的异质性。TOLM 声门上喉切除术是一种安全、有效的手术，与足够的功能、手术和肿瘤结果相关。需要进一步的研究来确定 TOLM 在晚期 LSCC 中的地位；同期双侧颈清扫术的作用和时机、气管切开术和饲管的适应症。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

This review aimed to investigate the surgical, functional, and oncological outcomes of transoral laser microsurgery supraglottic laryngectomy (TOLM-SGL) for cT1-T3 laryngeal cancers.PubMed, Scopus, and Cochrane Library were searched by two independent investigators for studies investigating the surgical, functional, and oncological outcomes of TOLM-SGL using the PRISMA statements. A bias analysis was carried out with MINORS.Twenty-four studies were included (937 patients), including 206 (25.9 %) cT1, 467 (58.7 %) cT2, and 123 (15.4 %) cT3 cases. Most patients were cN0 (63.9 %). The mean hospital stay of TOLM was 10.1 days. Aspiration (5.5 %), and bleeding (5.3 %) were the most prevalent complications. The laryngeal preservation rate was 93.7 %. Temporary tracheotomy was performed in 18.0 % of patients, with a mean time of decannulation of 6.8 days. A feeding tube was placed in 59.9 % of patients. The oral diet restarted after 6.4 days. Definitive gastrostomy was necessary in 2.4 % of cases. The 5-year OS and DFS were 70.1 % and 82.0 %, respectively. Distant metastasis, local, and regional recurrence occurred in 4.6 %, 11.6 %, and 5.1 % of patients. There was an important heterogeneity between studies for inclusion criteria, patient profiles, TOLM indications, and details of surgical, functional, and oncological outcomes.TOLM supraglottic laryngectomy is a safe, and effective procedure associated with adequate functional, surgical, and oncological outcomes. Future studies are needed to define the place of TOLM in advanced LSCC; the role and timing of concomitant bilateral neck dissection, the indications of tracheotomy and feeding tube.Copyright © 2024 Elsevier Ltd. All rights reserved.