糖酵解相关 lncRNA 在肿瘤进展中的调节功能：机制、事实和观点。
Regulatory function of glycolysis-related lncRNAs in tumor progression: Mechanism, facts, and perspectives.
发表日期：2024 Aug 31
作者：
Xinyi Peng, Shuhao Li, Anqi Zeng, Linjiang Song
来源：
BIOCHEMICAL PHARMACOLOGY
摘要：
代谢改变是癌症的一个标志，而能量代谢的重新编程，即所谓的“瓦尔堡效应”，长期以来一直与癌症有关。癌细胞利用糖酵解过程快速从葡萄糖、丙酮酸和乳酸制造能量，从而加速癌症的生长，糖酵解成为抗癌治疗的关键目标。最近关于长非编码RNA（lncRNA）的突破性发现为癌症发生机制翻开了新的篇章。人们广泛认为lncRNA通过癌细胞中的糖酵解调节能量代谢。 LncRNA 已被证明参与多种癌症过程，如增殖、凋亡、迁移、侵袭和化疗耐药，而糖酵解则因 lncRNA 的失调而增强或抑制。因此，癌症的生存和发展受到不同信号通路的影响。在这篇综述中，我们总结了 lncRNA 在多种癌症中的作用，并描述了它们在糖酵解中的作用机制。此外，还讨论了糖酵解和 lncRNA 在癌症治疗中的预测潜力。版权所有 © 2024。由 Elsevier Inc. 出版。
Altered metabolism is a hallmark of cancer, and reprogramming of energy metabolism, known as the "Warburg effect", has long been associated with cancer. Cancer cells use the process of glycolysis to quickly manufacture energy from glucose, pyruvic acid, and lactate, which in turn accelerates the growth of cancer and glycolysis becomes a key target for anti-cancer therapies. Recent groundbreaking discoveries regarding long noncoding RNAs (lncRNAs) have opened a new chapter in the mechanism of cancer occurrence. It is widely recognized that lncRNAs regulate energy metabolism through glycolysis in cancer cells. LncRNAs have been demonstrated to engage in several cancer processes such as proliferation, apoptosis, migration, invasion, and chemoresistance, whereas glycolysis is enhanced or inhibited by the dysregulation of lncRNAs. As a result, cancer survival and development are influenced by different signaling pathways. In this review, we summarize the roles of lncRNAs in a variety of cancers and describe the mechanisms underlying their role in glycolysis. Additionally, the predictive potential of glycolysis and lncRNAs in cancer therapy is discussed.Copyright © 2024. Published by Elsevier Inc.