作为持久性有机污染物（POP），全氟烷基物质（PFAS）可能会影响人类健康。我们的研究旨在探讨PFAS暴露与女性乳腺癌发病风险之间的前瞻性关联。通过十年后对金昌队列的全面跟踪，我们对135例乳腺癌（BC）发病病例进行了这项巢式病例对照研究。 540 个偏置配对控件。通过基线血清样本测试 PFAS 水平。采用条件逻辑回归和限制三次样条模型来研究 BC 发生风险以及与单一 PFAS 成分暴露相关的剂量反应。此外，还集成了分位数 g 计算模型 (Qgc)、随机森林模型 (RFM) 和贝叶斯核机器回归模型 (BKMR)，以估计 PFAS 暴露对 BC 发病风险的混合影响。 特定 PFAS 成分的暴露与乳腺癌发病风险增加呈正相关。通过将研究人群分为不同的基线绝经状态，PFHxS、PFNA、PFBA、PFUdA、PFOS 和 PFDA 表现出与 BC 发病风险类似的正相关。然而，与 PFOA、PFOS、PFUdA 和 9CL-PF3ONS 暴露相关的 BC 发病风险增加仅见于绝经前人群。 BKMR 和 Qgc 均显示，接触混合 PFAS 与乳腺癌风险增加相关，Qgc 特别表明比值比 (OR) 为 2.21（95% CI：1.53，3.19）。随机森林显示 PFBA、PFOS、PFHxS 和 PFDA 成为潜在影响乳腺癌发病率的主要因素。我们的研究结果表明 PFAS 暴露与乳腺癌发病率之间存在密切关联。绝经前女性应更加谨慎地对待 PFAS 暴露。版权所有 © 2024。由 Elsevier Inc. 出版。

As persistent organic pollutants (POPs), perfluoroalkyl substances (PFAS) may potentially impact human health. Our study aimed to investigate the prospective association between PFAS exposure and the incidence risk of breast cancer in females.By fully following the Jinchang Cohort after a decade, we conducted this nested case-control study with 135 incidence cases of breast cancer (BC) and 540 bias-paired controls. The PFAS levels were tested by baseline serum samples. Conditional logistic regression and a restricted cubic spline model were employed to investigate the BC incidence risks and the dose-response associated with single PFAS component exposure. Furthermore, the Quantile g-computation model (Qgc), random forest model (RFM), and bayesian kernel machine regression models (BKMR) were integrated to estimate the mixed effects of PFAS exposure on the incidence risk of BC.Exposures to specific PFAS components were positively associated with an increased incidence risk of breast cancer. By grouping the study population into different baseline menopausal statuses, PFHxS, PFNA, PFBA, PFUdA, PFOS, and PFDA demonstrated a similarly positive correlation with BC incidence risks. However, the increased incidence risks of BC associated with PFOA, PFOS, PFUdA, and 9CL-PF3ONS exposure were exclusively found in the premenopausal population. Both BKMR and Qgc revealed that exposure to mixed PFAS was associated with an increased risk of breast cancer, with Qgc specifically indicating an odds ratio (OR) of 2.21 (95% CI: 1.53, 3.19). Random forests showed that PFBA, PFOS, PFHxS, and PFDA emerged as predominant factors potentially influencing breast cancer incidence.Our findings suggest a strong association between PFAS exposure and the incidence of breast cancer. Premenopausal women should exercise more caution regarding PFAS exposure.Copyright © 2024. Published by Elsevier Inc.