促进抗癌：探索支链氨基酸催化对癌症和癌症免疫微环境的影响。
Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment.
发表日期：2024 Aug 31
作者：
Qianquan Ma, Haoyu Li, Zhihao Song, Zhili Deng, Wei Huang, Qing Liu
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL
摘要：
支链氨基酸 (BCAA) 的代谢对于哺乳动物的营养必需品至关重要。催化酶用于指导全身支链氨基酸氧化，从而参与各种代谢紊乱的发展。重新编程的代谢元件还负责恶性致癌过程，并有利于不同癌症周围独特的免疫抑制微环境的形成。与支链氨基酸功能障碍相关的无效免疫监视是一个新的研究课题。在这里，我们重点关注在癌症进展过程中导致代谢变化和免疫反应失调的支链氨基酸催化剂。我们总结了支链氨基酸催化的当前知识，强调了支链氨基酸代谢在癌症治疗中的有趣作用。版权所有 © 2024。由爱思唯尔公司出版。
Metabolism of Branched-chain amino acids (BCAAs) is essential for the nutrient necessities in mammals. Catalytic enzymes serve to direct the whole-body BCAAs oxidation which involve in the development of various metabolic disorders. The reprogrammed metabolic elements are also responsible for malignant oncogenic processes, and favor the formation of distinctive immunosuppressive microenvironment surrounding different cancers. The impotent immune surveillance related to BCAAs dysfunction is a novel topic to investigate. Here we focus on the BCAA catalysts that contribute to metabolic changes and dysregulated immune reactions in cancer progression. We summarize the current knowledge of BCAA catalyzation, highlighting the interesting roles of BCAA metabolism in the treatment of cancers.Copyright © 2024. Published by Elsevier Inc.