cGAS/STING 信号通路是先天免疫系统的重要组成部分，在感知细胞质 DNA、调节细胞衰老和促进肿瘤发生方面发挥着重要作用。最近的进展为多种病理生理环境中控制通路激活的分子机制、cGAS/STING 信号在细胞衰老中不可或缺的作用及其在癌症发生和抑制中的背景依赖性作用提供了新的线索。本综述总结了与 cGAS/STING 信号通路生物学及其参与衰老和肿瘤发生相关的当前知识。我们进一步探索 cGAS/STING 靶向治疗的临床意义和治疗潜力，并面临该领域的挑战。本综述重点关注分子机制和新兴药理学靶点，强调了未来研究利用 cGAS/STING 通路治疗衰老相关疾病和癌症的治疗潜力的重要性。对 cGAS/STING 信号传导调节机制的深入了解，以及疾病中相关的放松管制，再加上新型 cGAS/STING 调节剂的开发，为创建新颖有效的治疗策略带来了巨大希望。这些进步可以解决当前的治疗挑战，并释放 cGAS/STING 在治疗衰老相关疾病和肿瘤发生方面的全部潜力。版权所有 © 2024。由 Elsevier Ltd 出版。

The cGAS/STING signaling pathway is a crucial component of the innate immune system, playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and contributing to oncogenesis. Recent advances have shed new lights into the molecular mechanisms governing pathway activation in multiple pathophysiological settings, the indispensable roles of cGAS/STING signaling in cellular senescence, and its context-dependent roles in cancer development and suppression. This review summarizes current knowledge related to the biology of cGAS/STING signaling pathway and its participations into senescence and oncogenesis. We further explore the clinical implications and therapeutic potential for cGAS/STING targeted therapies, and faced challenges in the field. With a focus on molecular mechanisms and emerging pharmacological targets, this review underscores the importance of future studies to harness the therapeutic potential of the cGAS/STING pathway in treating senescence-related disorders and cancer. Advanced understanding of the regulatory mechanisms of cGAS/STING signaling, along with the associated deregulations in diseases, combined with the development of new classes of cGAS/STING modulators, holds great promise for creating novel and effective therapeutic strategies. These advancements could address current treatment challenges and unlock the full potential of cGAS/STING in treating senescence-related disorders and oncogenesis.Copyright © 2024. Published by Elsevier Ltd.