传统的宫颈癌化疗药物往往会引起明显的毒副作用和耐药性问题，凸显了迫切需要更加创新和有效的治疗策略。众所周知，镁合金具有可降解性和生物相容性。镁合金释放的降解产物Mg2、OH-和H2可以改变肿瘤微环境，提供潜在的抗肿瘤特性。我们探索了镁合金生物材料在宫颈癌治疗中的创新应用，研究了不同浓度的Mg2对宫颈癌细胞增殖和细胞死亡的影响。结果显示，不同浓度的Mg2通过将细胞周期阻滞在G0/G1期并诱导SiHa细胞凋亡，显着抑制宫颈癌，有效减少肿瘤细胞增殖。体内实验表明，20 mM Mg2组肿瘤体积最小，对宫颈癌的生物学特性表现出有效的抑制作用。这增强了这种生物材料作为局部抗肿瘤疗法的治疗潜力，并为镁在宫颈癌治疗中的潜在应用奠定了理论基础。© 2024。作者。

Traditional chemotherapy drugs for cervical cancer often cause significant toxic side effects and drug resistance problems, highlighting the urgent need for more innovative and effective treatment strategies. Magnesium alloy is known to be degradable and biocompatible. The release of degradation products Mg2+, OH-, and H2 from magnesium alloy can alter the tumor microenvironment, providing potential anti-tumor properties. We explored the innovative use of magnesium alloy biomaterials in the treatment of cervical cancer, investigating how various concentrations of Mg2+ on the proliferation and cell death of cervical cancer cells. The results revealed that varying concentrations of Mg2+ significantly inhibited cervical cancer by arresting the cell cycle in the G0/G1 phase and inducing apoptosis in SiHa cells, effectively reducing tumor cell proliferation. In vivo experiments demonstrated that 20 mM Mg2+ group had the smallest tumor volume, exhibiting a potent inhibitory effect on the biological characteristics of cervical cancer. This enhances the therapeutic potential of this biomaterial as a local anti-tumor therapy and lays a theoretical foundation for the potential application of magnesium in the treatment of cervical cancer.© 2024. The Author(s).