瘤周组织 (PTT):对命名约定的需求不断增加。
Peritumoral tissue (PTT): increasing need for naming convention.
发表日期:2024 Sep 02
作者:
Dzenis Koca, Behnoush Abedi-Ardekani, Joel LeMaoult, Laurent Guyon
来源:
BRITISH JOURNAL OF CANCER
摘要:
各种术语用于描述位于肿瘤附近、属于肿瘤起源器官的非恶性组织。传统上,这些组织有时被称为“正常邻近组织”,已被用作癌症研究中的对照,并被认为代表形态上健康的非癌组织。然而,随着 OMIC 技术的进步,人们越来越认识到此类组织与肿瘤组织和健康组织都有所不同。此外,人们越来越多地研究这些组织的性质、特征以及在癌症形成和进展中的作用。为了使该领域的未来研究更加协调和更容易获得,并反对普遍存在的常态观念,我们提倡需要标准化的命名约定。为此,我们建议使用中性且综合的术语“瘤周组织”以及缩写词“PTT”。虽然有关这些组织的大量数据是公开的,但由于缺乏样本收集程序的信息,这些数据的重复利用仍然受到限制。为了便于将来重复使用数据,我们建议在样本收集过程中应记录的功能列表。这些建议可以帮助定义标准操作程序。© 2024。作者。
Various terms are used to describe non-malignant tissue located in the proximity of a tumor, belonging to the organ from which the tumor originated. Traditionally, these tissues, sometimes called "normal adjacent tissue" have been used as controls in cancer studies, and were considered representative of morphologically healthy, non-cancerous tissue. However, with the advancement of OMIC technologies, such tissues are increasingly recognized to be distinct from both tumor and healthy tissues. Furthermore, properties, characteristics, and role of these tissues in cancer formation and progression is increasingly studied. In order to make future research in this area more harmonized and more accessible, as well as to counter the widespread perception of normalcy, we are advocating the need for standardized naming convention. For this purpose, we propose the use of neutral and comprehensive term "Peritumoral Tissue" along with the acronym "PTT". While significant amount of data on these tissues are publicly available, reuse of such data remains limited due to a lack of information on sample collection procedures. In order to facilitate future reuse of the data, we suggest a list of features that should be documented during sample collection procedures. These recommendations can aid the definition of Standard Operating Procedures.© 2024. The Author(s).