研究动态
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疾病和治疗中细胞死亡的先天免疫感应。

Innate immune sensing of cell death in disease and therapeutics.

发表日期:2024 Sep 02
作者: Si Ming Man, Thirumala-Devi Kanneganti
来源: CYTOKINE & GROWTH FACTOR REVIEWS

摘要:

先天免疫、细胞死亡和炎症是健康和疾病的许多方面的基础。在感知到病原体、病原体相关分子模式或损伤相关分子模式后,先天免疫系统会激活裂解性炎症细胞死亡,例如焦亡和全凋亡。这些基因定义的、受调节的细胞死亡途径不仅有助于宿主防御传染病,而且还促进导致癌症和炎症性疾病的病理表现。近年来,我们对潜在机制的了解迅速增长。然而,先天免疫细胞如何进一步感知垂死的细胞、细胞尸体及其释放的细胞因子、趋化因子和炎症信号分子,以及它们对进一步放大炎症、触发抗原呈递和激活适应性免疫的贡献尚不清楚。在这里,我们讨论先天免疫细胞中的模式识别和 PANoptosome 传感器如何识别和响应细胞死亡特征。我们还强调了潜在治疗开发的先天免疫反应的分子靶标。© 2024。Springer Nature Limited。
Innate immunity, cell death and inflammation underpin many aspects of health and disease. Upon sensing pathogens, pathogen-associated molecular patterns or damage-associated molecular patterns, the innate immune system activates lytic, inflammatory cell death, such as pyroptosis and PANoptosis. These genetically defined, regulated cell death pathways not only contribute to the host defence against infectious disease, but also promote pathological manifestations leading to cancer and inflammatory diseases. Our understanding of the underlying mechanisms has grown rapidly in recent years. However, how dying cells, cell corpses and their liberated cytokines, chemokines and inflammatory signalling molecules are further sensed by innate immune cells, and their contribution to further amplify inflammation, trigger antigen presentation and activate adaptive immunity, is less clear. Here, we discuss how pattern-recognition and PANoptosome sensors in innate immune cells recognize and respond to cell-death signatures. We also highlight molecular targets of the innate immune response for potential therapeutic development.© 2024. Springer Nature Limited.