立体定向穿刺活检是诊断不适合手术干预的颅内病变的重要方法。尽管如此，潜在的采样误差催生了提高诊断精度的创新方法。本研究将接受荧光素辅助无框架立体定向针活检的患者的结果与接受传统活检的患者的结果进行对比，以评估对诊断准确性和安全性的影响。这项研究包括患有对比增强颅内病变的患者，其中包括在同一机构接受荧光素辅助活检的前瞻性组和接受常规活检的回顾性组。我们收集了有关人口统计、手术细节、诊断结果和术后事件的数据。一项比较分析涉及 43 名接受荧光素辅助活检的患者与 77 名接受传统活检的患者。平均年龄为60.5岁。荧光素组的诊断成功率为93%，显着高于非荧光素组的70.1%（OR = 5.67；95%IC：1.59-20.24；p < 0.01）。两个队列的并发症发生率在统计学上相似。尽管立体定向穿刺活检具有既定的价值，但它很容易出现不准确性和并发症。人们已经研究了 5-ALA 和荧光素等基于荧光的辅助剂的应用，以提高诊断保真度并降低风险。这些技术可能最大限度地减少多次活检的必要性，缩短手术时间，并立即验证肿瘤的存在。荧光素辅助立体定向活检成为传统方法的有效、安全替代方案。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Stereotactic needle biopsy stands as a crucial method for diagnosing intracranial lesions unsuitable for surgical intervention. Nonetheless, the potential for sampling errors lead to innovative approaches to enhance diagnostic precision. This study contrasts the outcomes of patients undergoing fluorescein-assisted frameless stereotactic needle biopsy with those receiving traditional biopsies to evaluate the impact on diagnostic accuracy and safety. This study included patients with contrast-enhancing intracranial lesions, comprising a prospective group undergoing fluorescein-assisted biopsies and a retrospective group undergoing conventional biopsies at the same institution. We've collected data on demographics, procedural specifics, diagnostic outcomes, and postoperative events. A comparative analysis involved 43 patients who received fluorescein-assisted biopsies against 77 patients who underwent conventional biopsies. The average age was 60.5 years. The fluorescein group exhibited a 93% success rate in diagnosis, markedly higher than the 70.1% in the non-fluorescein group (OR = 5.67; 95%IC: 1.59-20.24; p < 0.01). The rate of complications was statistically similar across both cohorts. Despite its established value, stereotactic needle biopsy is susceptible to inaccuracies and complications. The application of fluorescence-based adjuncts like 5-ALA and fluorescein has been investigated to improve diagnostic fidelity and reduce risks. These technologies potentially minimize the necessity for multiple biopsies, decrease surgical duration, and provide immediate verification of tumor presence. Fluorescein-assisted stereotactic biopsy emerges as an effective, secure alternative to conventional methods.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.