Y 染色体嵌合体丢失 (mLOY) 对高龄男性的影响。
The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age.
发表日期：2024 Sep 02
作者：
Farid Abou Abdallah, Christine Abdel Massih, Charbel Attieh, Alain Chebly
来源：
Alzheimers & Dementia
摘要：
Y染色体长期以来被认为是一个“基因荒地”，只含有少数与男性性发育和精子发生相关的基因。然而，老年男性中 Y 染色体嵌合缺失 (mLOY) 的发现使人们重新审视 Y 染色体对健康的潜在影响以及癌症、阿尔茨海默病和心血管疾病等多种疾病的病理生理过程。因此，开发更灵敏的 mLOY 检测技术已成为一个紧迫的问题。在本文中，我们对有关 mLOY 的文献进行了全面回顾。此外，我们还讨论了有关 mLOY 的新发现以及促进老年男性疾病的潜在机制。© 2024。作者获得 Springer Nature B.V. 的独家许可。
The Y chromosome has long been considered to be a "genetic wasteland" harboring only few genes essentially involved in male sex development and spermatogenesis. However, the discovery of mosaic loss of the Y chromosome (mLOY) in older men has led to revisiting of the potential impact of the Y chromosome on health and the pathophysiological processes of multiple diseases such as cancer, Alzheimer's disease and cardiovascular disease. Hence, developing more sensitive techniques for the detection of mLOY has become an emergent concern. In this article, we present a comprehensive review of the literature regarding mLOY. Additionally, we discuss the emerging discoveries concerning mLOY as well as the underlying mechanisms promoting disease in men of advanced age.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.