由于癌症进展和转移涉及复杂的病理生理机制，目前的治疗方法缺乏疗效且具有显着的副作用。因此，建立新的抗癌策略至关重要。植物化学物质具有抗氧化、抗炎、抗突变、免疫调节、抗增殖、抗血管生成和抗转移等多种生物活性，可以通过抑制多种信号通路来调节癌症进展并干扰癌症发展的各个阶段。截至2023年12月，根据系统评价和荟萃分析的首选报告项目（PRISMA）标准，使用包括PubMed、Scopus和Science Direct在内的电子数据库进行了系统和全面的评价。排除不相关文章后，共111篇相关文章这篇系统综述中包含了文章。在当前的这篇综述中，重点介绍了癌症代谢的主要信号通路以及植物化学物质的有前途的抗癌作用。这是通过它们调节 AMP 激活蛋白激酶 (AMPK)/过氧化物酶体增殖物激活受体 - γ 共激活因子-1α (PGC-1α) 信号通路的能力实现的。 AMPK/PGC-1α 信号通路通过靶向能量稳态和线粒体生物发生、葡萄糖氧化和脂肪酸氧化，从而产生用于细胞生长的 ATP，在癌细胞代谢中发挥着至关重要的作用。因此，针对该信号通路可能代表一种新的癌症治疗方法。因此，通过调节 AMPK/PGC-1α 信号通路，生物碱、酚类化合物、萜烯/萜类化合物和各种植物化学物质已被引入作为有前景的抗癌剂。本综述还重点介绍了针对 AMPK/PGC-1α 通路的新型植物化学物质递送系统来对抗癌症。© 2024。作者。

Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy and have significant adverse effects. Therefore, it is essential to establish novel strategies for combating cancer. Phytochemicals, which possess multiple biological activities, such as antioxidant, anti-inflammatory, antimutagenic, immunomodulatory, antiproliferative, anti-angiogenesis, and antimetastatic properties, can regulate cancer progression and interfere in various stages of cancer development by suppressing various signaling pathways.The current systematic and comprehensive review was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria, using electronic databases, including PubMed, Scopus, and Science Direct, until the end of December 2023. After excluding unrelated articles, 111 related articles were included in this systematic review.In this current review, the major signaling pathways of cancer metabolism are highlighted with the promising anticancer role of phytochemicals. This was through their ability to regulate the AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) signaling pathway. The AMPK/PGC-1α signaling pathway plays a crucial role in cancer cell metabolism via targeting energy homeostasis and mitochondria biogenesis, glucose oxidation, and fatty acid oxidation, thereby generating ATP for cell growth. As a result, targeting this signaling pathway may represent a novel approach to cancer treatment. Accordingly, alkaloids, phenolic compounds, terpene/terpenoids, and miscellaneous phytochemicals have been introduced as promising anticancer agents by regulating the AMPK/PGC-1α signaling pathway. Novel delivery systems of phytochemicals targeting the AMPK/PGC-1α pathway in combating cancer are also highlighted in this review.© 2024. The Author(s).