通过自我报告的种族对原位导管癌进行的分析揭示了与结果相关的分子差异。
Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.
发表日期：2024 Sep 02
作者：
Siri H Strand, Kathleen E Houlahan, Vernal Branch, Thomas Lynch, Belén Rivero-Guitiérrez, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla McAuliffe, Christina Curtis, Kouros Owzar, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
导管原位癌 (DCIS) 是浸润性乳腺癌 (IBC) 的非必然前兆。研究表明，DCIS 结果因种族或民族而存在差异，但分子差异尚未得到调查。我们通过自我报告的种族 (SRR) 和黑人 (n = 99) 和白人 (n = 191) 大型 DCIS 病例对照队列研究中的女性进行纵向随访。基因表达和通路分析表明，在白人与黑人女性中，不同的基因和通路参与 DCIS 治疗后的诊断和同侧乳房结局（DCIS 或 IBC） 。我们通过 SRR 和结果组确定了 ER 和 HER2 表达、肿瘤微环境组成以及拷贝数变异的差异。我们的结果表明，不同的分子机制驱动黑人与白人女性的同侧乳腺事件的发生和随后的发生。© 2024。 ）。
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.© 2024. The Author(s).