基于二氧化锰的纳米材料在肿瘤诊断和治疗领域的进展。
Progress of Nanomaterials Based on Manganese Dioxide in the Field of Tumor Diagnosis and Therapy.
发表日期：2024
作者：
Lijuan Liang, Ming Jia, Min Zhao, Yiping Deng, Jun Tang, Xinghui He, Yilin Liu, Kexin Yan, Xin Yu, Hong Yang, Chunhong Li, Yao Li, Tao Li
来源：
BIOMEDICINE & PHARMACOTHERAPY
摘要：
作为一种关键的过渡金属氧化物，二氧化锰（MnO2）因其丰富的储量、多样的晶体结构和优异的性能而受到广泛关注。纳米级 MnO2 可以实现更小的粒径、更大的比表面积、优化的材料特性和扩展的应用可能性。随着该领域研究工作的蓬勃发展，二氧化锰已成为一种有前途的肿瘤诊断和治疗纳米材料。 MnO2 在调节肿瘤微环境（TME）方面的独特特性引起了人们的极大兴趣，导致用于肿瘤诊断和治疗的 MnO2 基纳米材料的研究迅速增长。此外，MnO2纳米材料在慢性炎症疾病的调节中也逐渐显现出来。在这篇综述中，我们主要总结了各种MnO2纳米材料在肿瘤诊断和治疗方面的最新进展。此外，我们讨论了 MnO2 纳米材料发展中当前的挑战和未来方向，同时也展望了它们的临床转化潜力。© 2024 Liang 等人。
As a pivotal transition metal oxide, manganese dioxide (MnO2) has garnered significant attention owing to its abundant reserves, diverse crystal structures and exceptional performance. Nanosizing MnO2 results in smaller particle sizes, larger specific surface areas, optimized material characteristics, and expanded application possibilities. With the burgeoning research efforts in this field, MnO2 has emerged as a promising nanomaterial for tumor diagnosis and therapy. The distinctive properties of MnO2 in regulating the tumor microenvironment (TME) have attracted considerable interest, leading to a rapid growth in research on MnO2-based nanomaterials for tumor diagnosis and treatment. Additionally, MnO2 nanomaterials are also gradually showing up in the regulation of chronic inflammatory diseases. In this review, we mainly summarized the recent advancements in various MnO2 nanomaterials for tumor diagnosis and therapy. Furthermore, we discuss the current challenges and future directions in the development of MnO2 nanomaterials, while also envisaging their potential for clinical translation.© 2024 Liang et al.