简介：帕金森病（PD）的特点是由于黑质多巴胺能神经元变性而导致纹状体多巴胺缺乏。症状包括运动迟缓、静止性震颤、姿势不稳定、肌肉僵硬和步态拖沓。唐松草传统上用于治疗神经退行性疾病。目的：本研究旨在探讨唐松草水乙醇提取物（AETF）对帕金森样症状的治疗潜力并探讨其潜在机制。方法：将 36 只白化小鼠随机分为 6 组 (n = 6)：正常对照组、疾病对照组、标准治疗组（左旋多巴/卡比多巴，100/25 mg/kg）和 3 个治疗组（AETF 200、400和 600 毫克/千克）。治疗前一小时，除正常对照组外，所有组均给予氟哌啶醇（1 mg/kg，腹腔注射）以诱导帕金森病。结果：行为分析显示运动功能、肌肉协调性显着改善 (P < .001)，并减少肌肉僵硬和震颤。 AETF 还可以减少氧化应激。大脑的组织学检查显示路易体、神经原纤维缠结和斑块形成减少。结论：AETF 通过减少神经退行性变、调节氧化应激、抑制核因子-κB (NF-κB) 和相关炎症细胞因子，如肿瘤坏死因子-α (TNF-α) 和白介素-6 的表达来缓解 PD 症状。 IL-6).© 作者 2024。

Introduction: Parkinson's disease (PD) is characterized by dopamine deficiency in the corpus striatum due to the degeneration of dopaminergic neurons in the substantia nigra. Symptoms include bradykinesia, resting tremors, unstable posture, muscular rigidity, and a shuffled gait. Thalictrum foetidum is traditionally used for neurodegenerative disorders. Objectives: This study aimed to explore the therapeutic potential of aqueous ethanolic extract of Thalictrum foetidum (AETF) against Parkinson-like symptoms and to investigate its underlying mechanism. Methodology: Thirty-six albino mice were randomly divided into 6 groups (n = 6): normal control, disease control, standard treatment (levodopa/carbidopa, 100/25 mg/kg), and 3 treatment groups (AETF at 200, 400, and 600 mg/kg). One hour before treatment, haloperidol (1 mg/kg, i. p.) was administered to induce Parkinson's disease in all groups except the normal control group. Results: Behavioral analysis showed significant improvement (P < .001) in motor function, muscular coordination, and reduced muscular rigidity and tremors. AETF also reduced oxidative stress. Histological examination of the brain showed reduced Lewy bodies, neurofibrillary tangles, and plaque formation. Conclusion: AETF alleviated PD symptoms by reducing neurodegeneration, modulating oxidative stress, and inhibiting the expression of nuclear factor-κB (NF-κB) and associated inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6).© The Author(s) 2024.