当前无蒂锯齿状病变的发生率:对未来临床实践的影响。
Current sessile serrated lesion incidence: implications for future clinical practice.
发表日期:2024 Sep 03
作者:
Emma Bone, Shiristi Kumar, Simon Richards, Andrew McCombie, Teresa Chalmers-Watson, Tamara Glyn, Tim Eglinton
来源:
Bone & Joint Journal
摘要:
无蒂锯齿状病变 (SSL) 占结直肠癌发病机制的 30%。随着多种分类的变化以及结肠镜检查设备和技术的改进,历史报告可能低估了 SSL 的真实发病率。本研究旨在确定一年内在新西兰坎特伯雷接受结肠镜检查的患者中 SSL 的发生率,并描述其临床和病理特征。搜索电子记录以识别自 2022 年 1 月 1 日起进行的所有下段内窥镜检查和息肉切除术至2022年12月1日(含)。患者的电子记录用于收集手术过程中切除的每个息肉的组织学分类、位置和大小。主要结果是发现一种或多种 SSL、腺瘤或增生性息肉的手术数量。次要结果包括组织学分类、每个息肉切除的位置和大小。研究期间完成了 4346 例手术。其中,64.1% (2786) 接受了息肉切除术,18.6% (808) 接受了至少一处 SSL 切除。对 9166 个息肉完成了个体息肉分析,发现切除的息肉中有 24.0% 是 SSL,并且主要位于右结肠(65.1% 右结肠、32.6% 左结肠、2.3% 直肠)。 SSL 通常<10mm (84.8%)。本研究发现与之前的研究相比,SSL 的发生率更高。这些结果提出了有关 SLL 率历史上是否被低估、SSL 检测率是否应作为关键绩效指标的问题,并引发了对使用计算机断层扫描结肠成像作为筛查工具的进一步担忧。© 2024 作者。约翰·威利 (John Wiley) 出版的 ANZ 外科杂志
Sessile serrated lesions (SSL) account for up to 30% of colorectal carcinoma pathogenesis. With multiple classification changes and improvements in colonoscopy equipment and technique, historical reporting may have underestimated the true incidence of SSLs. This study aimed to determine the incidence of SSLs in patients undergoing colonoscopic investigation in Canterbury, New Zealand over a 1-year period and describe their clinical and pathological characteristics.Electronic records were searched to identify all lower endoscopy procedures with polypectomy performed from 1 January 2022 to 1 December 2022 (inclusive). Patients' electronic records were used to collect histological classification, location and size of each polyp removed during their procedure. The primary outcome was the number of procedures that had one or more SSL, adenoma or hyperplastic polyp identified. Secondary outcomes included histological classification, location and size of each polyp removed.There were 4346 procedures completed during the study period. Of these, 64.1% (2786) had a polypectomy and 18.6% (808) had at least one SSL excised. Individual polyp analysis was completed on 9166 polyps and found that 24.0% of polyps removed were SSLs and they were found predominately in the right colon (65.1% right colon, 32.6% left colon, 2.3% rectum). SSLs were typically <10 mm (84.8%).This study found a higher incidence of SSLs compared to previous research. These results raise questions regarding whether SLL rates have been historically underestimated, whether SSL detection rate should be included as a key performance indicator and raises further concerns regarding the use of computed tomography colonography as a screening tool.© 2024 The Author(s). ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.