神经精神疾病对公共卫生提出了全球性挑战。与神经精神疾病病因相关的机制包括细胞凋亡、氧化应激和神经炎症。肿瘤坏死因子α是一种炎症细胞因子，介导神经精神疾病的病理生理学。因此，英夫利昔单抗对其的抑制可能为干预提供有价值的目标。英夫利昔单抗通常用于治疗炎症性疾病，包括溃疡性结肠炎、克罗恩病和类风湿性关节炎。最近，研究表明英夫利昔单抗可以改善认知功能障碍、抑郁、焦虑和生活质量。在此，我们回顾了当代知识，支持进一步将英夫利昔单抗定性为神经精神疾病的潜在治疗方法。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Neuropsychiatric disorders present a global challenge to public health. Mechanisms associated with neuropsychiatric disorders etiology include apoptosis, oxidative stress, and neuroinflammation. Tumor necrosis factor alpha, an inflammatory cytokine, mediates pathophysiology of neuropsychiatric disorders. Therefore, its inhibition by infliximab might afford a valuable target for intervention. Infliximab is commonly used to treat inflammatory diseases, including ulcerative colitis, Crohn's disease, and rheumatoid arthritis. Recently, it has been shown that infliximab improves cognitive dysfunction, depression, anxiety, and life quality. Here, we review contemporary knowledge supporting the need to further characterize infliximab as a potential treatment for neuropsychiatric disorders.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.