二甲双胍和 PI3K/AKT 信号通路：对癌症、心血管和中枢神经系统疾病的影响。
Metformin and the PI3K/AKT signaling pathway: implications for cancer, cardiovascular, and central nervous system diseases.
发表日期：2024 Sep 03
作者：
Hemin Ashayeri Ahmadabad, Somayeh Mohammadi Panah, Hojat Ghasemnejad-Berenji, Shabnam Ghojavand, Morteza Ghasemnejad-Berenji, Mohammad Rafi Khezri
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
最近的研究结果使我们在分子水平上了解了疾病，强调了上游细胞内通路作为潜在的治疗靶点。 PI3K/AKT 通路是细胞对环境变化反应的关键调节因子，在各种疾病中经常发生改变，使其成为有前景的干预靶点。二甲双胍是最著名的抗糖尿病药物，因其对癌症、炎症相关疾病、氧化应激和其他人类疾病的影响而闻名。众所周知，二甲双胍可调节 PI3K/AKT 通路的活性，从而产生多种结果。这种相互作用已在多种疾病中得到充分研究。因此，本综述旨在研究二甲双胍在癌症、心血管和中枢神经系统疾病中的 PI3K/AKT 调节特性。我们的研究结果表明，二甲双胍可有效治疗癌症和中枢神经系统疾病，并在预防和治疗心血管疾病方面发挥作用。这些见解支持二甲双胍在疾病管理综合策略中的潜力。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。
Recent findings have brought our understanding of diseases at the molecular level, highlighting upstream intracellular pathways as potential therapeutic targets. The PI3K/AKT pathway, a key regulator of cellular responses to environmental changes, is frequently altered in various diseases, making it a promising target for intervention. Metformin is the most known anti-diabetic agent that is known due to its effects on cancer, inflammatory-related diseases, oxidative stress, and other human diseases. It is clearly understood that metformin modulates the activity of the PI3K/AKT pathway leading to a wide variety of outcomes. This interaction has been well-studied in various diseases. Therefore, this review aims to examine PI3K/AKT-modulating properties of metformin in cancer, cardiovascular, and central nervous system diseases. Our findings indicate that metformin is effective in treating cancer and CNS diseases, and plays a role in both the prevention and treatment of cardiovascular diseases. These insights support the potential of metformin in comprehensive strategies for disease management.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.