套索肽是核糖体合成的和翻译后修饰的肽，主要由细菌和一些古细菌产生。链霉菌套索肽因其抗菌、抗癌和抗病毒特性而闻名。然而，对它们在次生代谢物的形态和产生中的作用的了解仍然有限。我们在链霉菌基因组中鉴定了一个以前未知的套索肽基因簇。 L06。该基因簇 (LASS) 产生两种不同的套索肽，即 morphosin-1 和 - 2。值得注意的是，morphosin-2 是套索肽新亚家族的成员，BGC 具有相似的结构。当 LASS 在不同的链霉菌宿主中表达时，它会导致令人兴奋的表型变化，包括孢子的缺失和气生菌丝体发育的破坏。在其中一个宿主体内，LASS 甚至引发了抗生素的形成。这些发现开启了一个充满可能性的世界，表明吗啡肽在塑造链霉菌形态和生化发育方面的潜在作用。© 2024。作者。

Lasso peptides, ribosomally synthesized and post-translationally modified peptides, are primarily produced by bacteria and some archaea. Streptomyces lasso peptides have been known for their antimicrobial, anticancer, and antiviral properties. However, understanding their role in the morphology and production of secondary metabolites remains limited. We identified a previously unknown lasso peptide gene cluster in the genome of Streptomyces sp. L06. This gene cluster (LASS) produces two distinct lasso peptides, morphosin-1 and - 2. Notably, morphosin-2 is a member of a new subfamily of lasso peptides, with BGCs exhibiting a similar structure. When LASS was expressed in different Streptomyces hosts, it led to exciting phenotypic changes, including the absence of spores and damage in aerial mycelium development. In one of the hosts, LASS even triggered antibiotic formation. These findings open up a world of possibilities, suggesting the potential role of morphosins in shaping Streptomyces' morphological and biochemical development.© 2024. The Author(s).