新兴研究表明，高氨血症可能会增加肝性脑病（HE）的可能性，肝性脑病是一种与肝硬化患者循环氨水平升高相关的疾病。然而，一些研究表明，血氨水平可能与 HE 的严重程度并不总是相关，凸显了这种情况的复杂病理生理学。通过 PubMed、Scopus、Embase、Web of Science 和 Virtual Health Library 进行的系统回顾和荟萃分析为了解决这一复杂性，我们分析和比较了已发表的各种实验室参数的数据，包括患有和不患有 HE 的肝硬化患者的循环氨、血肌酐、白蛋白、钠和炎症标志物。这项综合综述包括来自 5 个国家的 81 项研究截至 2024 年 6 月，信誉良好的数据库显示，肝硬化 HE 患者（尤其是明显 HE 患者）的循环氨水平显着升高。值得注意的是，HE 患者的循环肌酐、白蛋白、钠、白细胞介素 6 (IL-6) 和肿瘤坏死因子 α (TNFα) 发生显着变化。这些发现表明氨与 HE 之间存在关联，并强调了重要性在设计 HE 新治疗策略时考虑其他血液参数，如肌酐、白蛋白、钠和促炎细胞因子。版权所有：© 2024 Sepehrinezhad 等人。这是一篇根据知识共享署名许可条款分发的开放获取文章，允许在任何媒体上不受限制地使用、分发和复制，前提是注明原始作者和来源。

Emerging research suggests that hyperammonemia may enhance the probability of hepatic encephalopathy (HE), a condition associated with elevated levels of circulating ammonia in patients with cirrhosis. However, some studies indicate that blood ammonia levels may not consistently correlate with the severity of HE, highlighting the complex pathophysiology of this condition.A systematic review and meta-analysis through PubMed, Scopus, Embase, Web of Science, and Virtual Health Library were conducted to address this complexity, analyzing and comparing published data on various laboratory parameters, including circulating ammonia, blood creatinine, albumin, sodium, and inflammation markers in cirrhotic patients, both with and without HE.This comprehensive review, which included 81 studies from five reputable databases until June 2024, revealed a significant increase in circulating ammonia levels in cirrhotic patients with HE, particularly those with overt HE. Notably, significant alterations were observed in the circulating creatinine, albumin, sodium, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFα) in HE patients.These findings suggest an association between ammonia and HE and underscore the importance of considering other blood parameters such as creatinine, albumin, sodium, and pro-inflammatory cytokines when devising new treatment strategies for HE.Copyright: © 2024 Sepehrinezhad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.